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The objective of this study is to investigate the use of aspirin on prevention of different cancers among Chinese users. This population\u2010based study utilized database from the Hong Kong Hospital Authority; adults with aspirin prescription for at least 6 months between 2000 and 2004 were included and followed up until 2013. Aspirin users were age\u2010sex matched with non\u2010aspirin users at a 1:2 ratio. Incidences of cancer were the primary outcome measured by relative risk (RR). A total of 204,170 aspirin users and 408,339 non\u2010aspirin users were included, with the mean age 67.5 years, 7.7 years average duration of aspirin prescription and 80 mg as the median dose of aspirin. Cancer incidences were found in 26,929 (13.2%) aspirin users and 70,755 (17.3%) non\u2010aspirin users. Compared with patients who had not been prescribed aspirin, aspirin usage led to significant reduction of cancers in liver (RR: 0.49), stomach (RR: 0.42), colorectum (RR: 0.71), lung (RR: 0.65), pancreas (RR: 0.54), oesophagus (RR: 0.59) and leukaemia (RR: 0.67). There was no demonstrable reduction of kidney cancer, bladder cancer, prostate cancer and multiple myeloma in association with the usage of aspirin. Risk of breast cancer was shown to marginally increase (RR: 1.14) with aspirin usage. This study demonstrated that the long\u2010term use of low\u2010dose aspirin is associated with the reduction in risk of various cancers but not for breast cancer. Further investigation is needed before promoting aspirin as a primary chemoprotective agent.<\/jats:p>","DOI":"10.1002\/ijc.32083","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T22:05:56Z","timestamp":1545429956000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Long\u2010term use of low\u2010dose aspirin for cancer prevention: A 10\u2010year population cohort study in Hong Kong"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5580-7686","authenticated-orcid":false,"given":"Kelvin K.F.","family":"Tsoi","sequence":"first","affiliation":[{"name":"Stanley Ho Big Data Decision Analytics Research Centre The Chinese University of Hong Kong  Shatin Hong Kong"},{"name":"Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong  Shatin Hong 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