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Inherited mutations in <jats:italic>BRCA1\/2<\/jats:italic> account for about 13% of all cases and additional genes that may contribute to the missing heritability need to be investigated. In our study, a well\u2010characterized series of 523 male BC (MBC) patients from the Italian multicenter study on MBC, enriched for non\u2010<jats:italic>BRCA1\/2<\/jats:italic> MBC cases, was screened by a multigene custom panel of 50 cancer\u2010associated genes. The main clinical\u2010pathologic characteristics of MBC in pathogenic variant carriers and non\u2010carriers were also compared. <jats:italic>BRCA1\/2<\/jats:italic> pathogenic variants were detected in twenty patients, thus, a total of 503 non\u2010<jats:italic>BRCA1\/2<\/jats:italic> MBC patients were examined in our study. Twenty\u2010seven of the non\u2010<jats:italic>BRCA1\/2<\/jats:italic> MBC patients were carriers of germline pathogenic variants in other genes, including two <jats:italic>APC<\/jats:italic> p.Ile1307Lys variant carriers and one <jats:italic>MUTYH<\/jats:italic> biallelic variant carrier. <jats:italic>PALB2<\/jats:italic> was the most frequently altered gene (1.2%) and <jats:italic>PALB2<\/jats:italic> pathogenic variants were significantly associated with high risk of MBC. Non\u2010<jats:italic>BRCA1\/2<\/jats:italic> pathogenic variant carriers were more likely to have personal (<jats:italic>p<\/jats:italic> = 0.0005) and family (<jats:italic>p<\/jats:italic> = 0.007) history of cancer. Results of our study support a central role of <jats:italic>PALB2<\/jats:italic> in MBC susceptibility and show a low impact of <jats:italic>CHEK2<\/jats:italic> on MBC predisposition in the Italian population. Overall, our data indicate that a multigene testing approach may benefit from appropriately selected patients with implications for clinical management and counseling of MBC patients and their family members.<\/jats:p>","DOI":"10.1002\/ijc.32106","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T16:52:53Z","timestamp":1546966373000},"page":"390-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Insight into genetic susceptibility to male breast cancer by multigene panel testing: Results from a multicenter study in Italy"],"prefix":"10.1002","volume":"145","author":[{"given":"Piera","family":"Rizzolo","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Zelli","sequence":"additional","affiliation":[{"name":"Department of Molecular 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