{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:53:39Z","timestamp":1769151219215,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["809195"],"award-info":[{"award-number":["809195"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32\u2010CA009529"],"award-info":[{"award-number":["T32\u2010CA009529"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1 CA164920"],"award-info":[{"award-number":["UM1 CA164920"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1 TR001875"],"award-info":[{"award-number":["TL1 TR001875"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["145684"],"award-info":[{"award-number":["145684"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["288704"],"award-info":[{"award-number":["288704"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["454508"],"award-info":[{"award-number":["454508"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RO1CA159868"],"award-info":[{"award-number":["1RO1CA159868"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:p>Benign breast disease (BBD) is an established breast cancer (BC) risk factor, but it is unclear whether the magnitude of the association applies to women at familial or genetic risk. This information is needed to improve BC risk assessment in clinical settings. Using the Prospective Family Study Cohort, we used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of BBD with BC risk. We also examined whether the association with BBD differed by underlying familial risk profile (FRP), calculated using absolute risk estimates from the Breast Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) model. During 176,756 person\u2010years of follow\u2010up (median: 10.9 years, maximum: 23.7) of 17,154 women unaffected with BC at baseline, we observed 968 incident cases of BC. A total of 4,704 (27%) women reported a history of BBD diagnosis at baseline. A history of BBD was associated with a greater risk of BC: HR\u2009=\u20091.31 (95% CI: 1.14\u20131.50), and did not differ by underlying FRP, with HRs of 1.35 (95% CI: 1.11\u20131.65), 1.26 (95% CI: 1.00\u20131.60), and 1.40 (95% CI: 1.01\u20131.93), for categories of full\u2010lifetime BOADICEA score &lt;20%, 20 to &lt;35%, \u226535%, respectively. There was no difference in the association for women with <jats:italic>BRCA1<\/jats:italic> mutations (HR: 1.64; 95% CI: 1.04\u20132.58), women with <jats:italic>BRCA2<\/jats:italic> mutations (HR: 1.34; 95% CI: 0.78\u20132.3) or for women without a known <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation (HR: 1.31; 95% CI: 1.13\u20131.53) (<jats:italic>p<\/jats:italic><jats:sub>interaction<\/jats:sub>\u2009=\u20090.95). Women with a history of BBD have an increased risk of BC that is independent of, and multiplies, their underlying familial and genetic risk.<\/jats:p>","DOI":"10.1002\/ijc.32112","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T16:24:10Z","timestamp":1549470250000},"page":"370-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Benign breast disease increases breast cancer risk independent of underlying familial risk profile: Findings from a Prospective Family Study Cohort"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-8599","authenticated-orcid":false,"given":"Nur","family":"Zeinomar","sequence":"first","affiliation":[{"name":"Department of Epidemiology Mailman School of Public Health, Columbia University  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly\u2010Anne","family":"Phillips","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics The University of Melbourne  Parkville VIC Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne VIC Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B.","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Fox Chase Cancer Center  Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics The University of Melbourne  Parkville VIC Australia"},{"name":"Cancer Epidemiology and Intelligence Division Cancer Council Victoria  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian S.","family":"Dite","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics The University of Melbourne  Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"MacInnis","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics The University of Melbourne  Parkville VIC Australia"},{"name":"Cancer Epidemiology and Intelligence Division Cancer Council Victoria  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Mailman School of Public Health, Columbia University  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca D.","family":"Kehm","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Mailman School of Public Health, Columbia University  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-7635","authenticated-orcid":false,"given":"Julia A.","family":"Knight","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Sinai Health System  Toronto ON Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa C.","family":"Southey","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Laboratory, Department of Pathology The University of Melbourne  Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center  New York NY"},{"name":"Department of Pediatrics and Medicine Columbia University  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics The University of Melbourne  Parkville VIC Australia"},{"name":"Cancer Epidemiology and Intelligence Division Cancer Council Victoria  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue\u2010Anne","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent's Hospital The University of Melbourne  Parkville VIC Australia"},{"name":"Department of Medical Oncology St Vincent's Hospital  Fitzroy VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Prince of Wales Clinical School, University of New South Wales  Sydney NSW Australia"},{"name":"Department of Medical Oncology Prince of Wales Hospital  Randwick NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prue C.","family":"Weideman","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics The University of Melbourne  Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gord","family":"Glendon","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Sinai Health System  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Nesci","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"kConFab Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute Sinai Health System  Toronto ON Canada"},{"name":"Departments of Molecular Genetics and Laboratory Medicine and Pathobiology University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saundra S.","family":"Buys","sequence":"additional","affiliation":[{"name":"Department of Medicine and Huntsman Cancer Institute University of Utah Health Sciences Center  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Medicine and Stanford Cancer Institute Stanford University School of Medicine  Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Hopper","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics The University of Melbourne  Parkville VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-5033","authenticated-orcid":false,"given":"Mary Beth","family":"Terry","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Mailman School of Public Health, Columbia University  New York NY"},{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center  New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.09.022"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29766"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044383"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930615)71:12<3896::AID-CNCR2820711217>3.0.CO;2-I"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114995"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200606000-00001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920315)69:6<1408::AID-CNCR2820690617>3.0.CO;2-C"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1999.tb00789.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200204000-00003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114594"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3254-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930215)71:4<1258::AID-CNCR2820710415>3.0.CO;2-I"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22136"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0217"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480070057030"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9508-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv118"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr801"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2000.tb124064.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-6129-x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1377"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0153-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604305"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602175"},{"key":"e_1_2_8_28_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program.SEER*Stat Database: Incidence\u2014SEER 13 Regs Research Data Nov 2011 Sub (1992\u20102009) <Katrina\/Rita Population Adjustment>\u2014Linked To County Attributes\u2014Total U.S.ed. 2011."},{"key":"e_1_2_8_29_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program.SEER*Stat Database: Incidence\u2014SEER 18 Regs Research Data Nov 2011 Sub (2000\u20102009) <Katrina\/Rita Population Adjustment>\u2014Linked To County Attributes\u2014Total U.S.ed. 2011."},{"key":"e_1_2_8_30_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program.SEER*Stat Database: Incidence\u2014SEER 9 Regs Research Data Nov 2011 Sub (1973\u20102009) <Katrina\/Rita Population Adjustment>\u2014Linked To County Attributes\u2014Total U.S.ed. 2011."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.730"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2007.00388.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2015.07.013"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1407164"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24674"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31528"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.32112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.32112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:06:39Z","timestamp":1694001999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.32112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,20]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,7,15]]}},"alternative-id":["10.1002\/ijc.32112"],"URL":"https:\/\/doi.org\/10.1002\/ijc.32112","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,20]]},"assertion":[{"value":"2018-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}