{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:29:51Z","timestamp":1763807391090,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sanofi Pasteur MSD","award":["MISP# 57025: GDS14E"],"award-info":[{"award-number":["MISP# 57025: GDS14E"]}]},{"name":"SelfScreen"},{"name":"Gene-First"},{"name":"Genomica; LifeRiver; Euroimmun; Qiagen; Cepheid; Hologic; Merck Sharp & Dohme Limited; The Beatson Cancer Charity; Sanofi-Pasteur"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,7,15]]},"abstract":"<jats:p>To assess the excess risk of HPV\u2010associated cancer (HPVaC) in two at\u2010risk groups\u2014women with a previous diagnosis of high grade cervical intraepithelial neoplasia (CIN3) and both men and women treated for non\u2010cervical pre\u2010invasive anogenital disease. All CIN3 cases diagnosed in 1989\u20132015 in Scotland were extracted from the Scottish cancer registry (SMR06). All cases of pre\u2010invasive penile, anal, vulval, and vaginal disease diagnosed in 1990\u20132015 were identified within the NHS pathology databases in the two largest NHS health boards in Scotland. Both were linked to SMR06 to extract subsequent incidence of HPVaC following the diagnosis of CIN3 or pre\u2010invasive disease. Standardised incidence ratios were calculated for the risk of acquiring HPVaC for the two at\u2010risk groups compared to the general Scottish population. Among 69,714 females in Scotland diagnosed with CIN3 (890,360.9 person\u2010years), 179 developed non\u2010cervical HPVaC. CIN3 cases were at 3.2\u2010fold (95% CI: 2.7 to 3.7) increased risk of developing non\u2010cervical HPVaC, compared to the general female population. Among 1,235 patients diagnosed with non\u2010cervical pre\u2010invasive disease (9,667.4 person\u2010years), 47 developed HPVaC. Individuals with non\u2010cervical pre\u2010invasive disease had a substantially increased risk of developing HPVaC \u2010 15.5\u2010fold (95% CI: 11.1 to 21.1) increased risk for females and 28\u2010fold (11.3 to 57.7) increased risk for males. We report a significant additional risk of HPV\u2010associated cancer in those have been diagnosed with pre\u2010invasive HPV\u2010associated lesions including but not confined to the cervix. Uncovering the natural history of pre\u2010invasive disease has potential for determining screening, prevention and treatment.<\/jats:p>","DOI":"10.1002\/ijc.32126","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T20:33:56Z","timestamp":1547670836000},"page":"427-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased risk of HPV\u2010associated genital cancers in men and women as a consequence of pre\u2010invasive disease"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-3209","authenticated-orcid":false,"given":"Jiafeng","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics University of Strathclyde  Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-5409","authenticated-orcid":false,"given":"Kimberley","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of Strathclyde  Glasgow Scotland"},{"name":"Information Services Division NHS National Services Scotland  Edinburgh Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Cuschieri","sequence":"additional","affiliation":[{"name":"Scottish HPV Reference Laboratory Royal Infirmary of Edinburgh  Edinburgh Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-307X","authenticated-orcid":false,"given":"Kevin G.","family":"Pollock","sequence":"additional","affiliation":[{"name":"Vaccine Preventable Diseases Health Protection Scotland  Glasgow Scotland"},{"name":"School of Health &amp; Life Sciences Glasgow Caledonian University  Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan C.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Sussex Cancer Centre Royal Sussex County Hospital  Brighton Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Millan","sequence":"additional","affiliation":[{"name":"Department of Pathology the Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde  Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Pathology the Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde  Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila V.","family":"Graham","sequence":"additional","affiliation":[{"name":"MRC\u2010University of Glasgow Centre for Virus Research University of Glasgow  Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair R.W.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Edinburgh  Edinburgh Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E.","family":"Cruickshank","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Sciences University of Aberdeen, 2nd Floor, Aberdeen Maternity Hospital  Aberdeen Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Edinburgh  Edinburgh Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Wakeham","sequence":"additional","affiliation":[{"name":"Sussex Cancer Centre Royal Sussex County Hospital  Brighton Scotland"},{"name":"Institute of Cancer Sciences University of Glasgow  Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"ISD Scotland. 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