{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:56:51Z","timestamp":1769605011039,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Project no. P301\/12\/1734"],"award-info":[{"award-number":["Project no. P301\/12\/1734"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["CAM\u2010PaC grant agreement no 602783"],"award-info":[{"award-number":["CAM\u2010PaC grant agreement no 602783"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["FIMP, CUP_J33G13000210001"],"award-info":[{"award-number":["FIMP, CUP_J33G13000210001"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Project no. 16\u201028375A"],"award-info":[{"award-number":["Project no. 16\u201028375A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"National Research Development and Innovation Office","doi-asserted-by":"publisher","award":["Economic Development and Innovation Operative Prog"],"award-info":[{"award-number":["Economic Development and Innovation Operative Prog"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"National Research Development and Innovation Office","doi-asserted-by":"publisher","award":["Project Grants (K116634 and KH125678)"],"award-info":[{"award-number":["Project Grants (K116634 and KH125678)"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Rare truncating <jats:italic>BRCA2<\/jats:italic> K3326X (rs11571833) and pathogenic <jats:italic>CHEK2<\/jats:italic> I157T (rs17879961) variants have previously been implicated in familial pancreatic ductal adenocarcinoma (PDAC), but not in sporadic cases. The effect of both mutations in important DNA repair genes on sporadic PDAC risk may shed light on the genetic architecture of this disease. Both mutations were genotyped in germline DNA from 2,935 sporadic PDAC cases and 5,626 control subjects within the PANcreatic Disease ReseArch (PANDoRA) consortium. Risk estimates were evaluated using multivariate unconditional logistic regression with adjustment for possible confounders such as sex, age and country of origin. Statistical analyses were two\u2010sided with <jats:italic>p<\/jats:italic> values &lt;0.05 considered significant. K3326X and I157T were associated with increased risk of developing sporadic PDAC (odds ratio (OR<jats:sub>dom<\/jats:sub>)\u2009= 1.78, 95% confidence interval (CI)\u2009= 1.26\u20132.52, <jats:italic>p<\/jats:italic> = 1.19 \u00d7 10<jats:sup>\u22123<\/jats:sup> and OR<jats:sub>dom<\/jats:sub> = 1.74, 95% CI\u2009= 1.15\u20132.63, <jats:italic>p<\/jats:italic> = 8.57 \u00d7 10<jats:sup>\u22123<\/jats:sup>, respectively). Neither mutation was significantly associated with risk of developing early\u2010onset PDAC. This retrospective study demonstrates novel risk estimates of K3326X and I157T in sporadic PDAC which suggest that upon validation and in combination with other established genetic and non\u2010genetic risk factors, these mutations may be used to improve pancreatic cancer risk assessment in European populations. Identification of carriers of these risk alleles as high\u2010risk groups may also facilitate screening or prevention strategies for such individuals, regardless of family history.<\/jats:p>","DOI":"10.1002\/ijc.32127","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T17:17:06Z","timestamp":1548350226000},"page":"686-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Germline <i>BRCA2<\/i> K3326X and <i>CHEK2<\/i> I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-5008","authenticated-orcid":false,"given":"O.","family":"Obazee","sequence":"first","affiliation":[{"name":"Genomic Epidemiology Group German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Archibugi","sequence":"additional","affiliation":[{"name":"Digestive and Liver Disease Unit, Pancreatic Disorders Clinic S. Andrea Hospital, University of Sapienza  Rome Italy"},{"name":"Pancreatico\/Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Andriulli","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Research Laboratory, Department of Oncology IRCCS Scientific Institute and Regional General Hospital \u201cCasa Sollievo della Sofferenza\u201d  San Giovanni Rotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Soucek","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacogenomics, Biomedical Centre, Faculty of Medicine in Plzen Charles University in Prague  Plzen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ma\u0142ecka\u2010Panas","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Diseases Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ivanauskas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-6811","authenticated-orcid":false,"given":"M.","family":"Gazouli","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Laboratory of Biology Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Pausch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein\u2010, Viszeral\u2010 und Transplantationschirurgie  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Lawlor","sequence":"additional","affiliation":[{"name":"ARC\u2010Net, Applied Research on Cancer Centre University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Cavestro","sequence":"additional","affiliation":[{"name":"Gastroenterology and Gastrointestinal Endoscopy Unit Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Milanetto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology \u2013DiSCOG University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Gastrointestinal Endoscopy Unit Vita\u2010Salute San Raffaele University, IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology \u2013DiSCOG University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and 1st Department of Medicine University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Szentesi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and 1st Department of Medicine University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Radu","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. E.","family":"Theodoropoulos","sequence":"additional","affiliation":[{"name":"First Propaedeutic Surgical Department, \"Hippocratio\" General Hospital Athens Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Pathologisches Institut der Universit\u00e4t Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Division of Preventive Oncology German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)  Heidelberg Germany"},{"name":"German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Vodickova","sequence":"additional","affiliation":[{"name":"Institute of Biology and Medical Genetics 1st Medical Faculty, Charles University, Prague and Biomedical Center, Faculty of Medicine in Pilsen, Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Katzke","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-9944","authenticated-orcid":false,"given":"D.","family":"Campa","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Universit\u00e0 di Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Strobel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein\u2010, Viszeral\u2010 und Transplantationschirurgie  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein\u2010, Viszeral\u2010 und Transplantationschirurgie  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pezzilli","sequence":"additional","affiliation":[{"name":"Pancreas Unit, Department of Digestive System Sant'Orsola\u2010Malpighi Hospital  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Federici","sequence":"additional","affiliation":[{"name":"Department of Massa Carrara Oncological Azienda USL Toscana Nord Ovest  Carrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Mohelnikova\u2010Duchonova","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Boggi","sequence":"additional","affiliation":[{"name":"Division of General and Transplant Surgery Pisa University Hospital  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lemstrova","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine and Dentistry Palacky University Olomouc and University Hospital Olomouc  Olomouc Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Oncology Herlev and Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-4133","authenticated-orcid":false,"given":"S. E.","family":"Bojesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Herlev and Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Herlev and Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. V.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Oncology Herlev and Gentofte Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Capurso","sequence":"additional","affiliation":[{"name":"Digestive and Liver Disease Unit, Pancreatic Disorders Clinic S. Andrea Hospital, University of Sapienza  Rome Italy"},{"name":"Pancreatico\/Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Pazienza","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Research Laboratory, Department of Oncology IRCCS Scientific Institute and Regional General Hospital \u201cCasa Sollievo della Sofferenza\u201d  San Giovanni Rotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Dervenis","sequence":"additional","affiliation":[{"name":"Department of Surgery Konstantopouleion General Hospital of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sperti","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology \u2013DiSCOG University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mambrini","sequence":"additional","affiliation":[{"name":"Department of Massa Carrara Oncological Azienda USL Toscana Nord Ovest  Carrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hackert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein\u2010, Viszeral\u2010 und Transplantationschirurgie  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3751-3929","authenticated-orcid":false,"given":"R.","family":"Kaaks","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Basso","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University\u2010Hospital of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Talar\u2010Wojnarowska","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Diseases Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Maiello","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Research Laboratory, Department of Oncology IRCCS Scientific Institute and Regional General Hospital \u201cCasa Sollievo della Sofferenza\u201d  San Giovanni Rotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Izbicki","sequence":"additional","affiliation":[{"name":"Department of General Visceral and Thoracic Surgery, University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Cuk","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. U.","family":"Saum","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cantore","sequence":"additional","affiliation":[{"name":"Department of Massa Carrara Oncological Azienda USL Toscana Nord Ovest  Carrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kupcinskas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Research Laboratory, Department of Oncology IRCCS Scientific Institute and Regional General Hospital \u201cCasa Sollievo della Sofferenza\u201d  San Giovanni Rotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Delle Fave","sequence":"additional","affiliation":[{"name":"Digestive and Liver Disease Unit, Pancreatic Disorders Clinic S. Andrea Hospital, University of Sapienza  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Landi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Universit\u00e0 di Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Salvia","sequence":"additional","affiliation":[{"name":"Department of Surgery Pancreas Institute, University and Hospital Trust of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Fogar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University\u2010Hospital of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. K.","family":"Vashist","sequence":"additional","affiliation":[{"name":"Department of General Visceral and Thoracic Surgery, University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Section for Visceral Surgery Department of Surgery, Kantonsspital Aarau AG  Aarau Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-739X","authenticated-orcid":false,"given":"A.","family":"Scarpa","sequence":"additional","affiliation":[{"name":"ARC\u2010Net, Applied Research on Cancer Centre University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vodicka","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Czech Academy of Science, Prague and Institute of Biology and Medical Genetics, 1<sup>st<\/sup> Medical Faculty, Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tjaden","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein\u2010, Viszeral\u2010 und Transplantationschirurgie  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Iskierka\u2010Jazdzewska","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4261-4583","authenticated-orcid":false,"given":"F.","family":"Canzian","sequence":"additional","affiliation":[{"name":"Genomic Epidemiology Group German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62307-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.15001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2009.04.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103206"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101220"},{"key":"e_1_2_7_7_1","first-page":"5360","article-title":"Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas","volume":"56","author":"Goggins M","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14169"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-253"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208411"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25148"},{"key":"e_1_2_7_12_1","first-page":"JCO2017723502","article-title":"Deleterious Germline mutations in patients with apparently sporadic pancreatic adenocarcinoma","volume":"2","author":"Shindo K","year":"2017","journal-title":"J Clin Oncol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/426403"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00527-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204811"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35071124"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2016.217"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.09.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0106"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02942-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv037"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210739"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2563"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv315"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33542"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm127"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","unstructured":"Kaczmarek\u2010Ry\u015bM ZiemnickaK HryhorowiczST G\u00f3rczakK Hoppe\u2010Go\u0142\u0119biewskaJ Skrzypczak\u2010Zieli\u0144skaM et al. The c.470 T\u2009>\u2009C CHEK2 missense variant increases the risk of differentiated thyroid carcinoma in the Great Poland population. Hered Cancer Clin Pract [Internet]. 2015;13. Available from:http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4367841\/","DOI":"10.1186\/s13053-015-0030-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20299"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.6228"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-014-9755-y"},{"key":"e_1_2_7_32_1","first-page":"990","article-title":"Cancer susceptibility of mice with a homozygous deletion in the COOH\u2010terminal domain of the Brca2 gene","volume":"62","author":"McAllister KA","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_7_33_1","first-page":"3441","article-title":"Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma\u2010radiation and premature senescence","volume":"58","author":"Morimatsu M","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.041"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw172"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-16-0269"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20210"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10863"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.32127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T15:00:13Z","timestamp":1694358013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.32127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/ijc.32127"],"URL":"https:\/\/doi.org\/10.1002\/ijc.32127","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]},"assertion":[{"value":"2018-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}