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Many new cases of OC\u2010SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC\u2010SCC in nonsmoking HPV negative patients. We compared the oral microbiome of HPV\u2010negative nonsmoker OC\u2010SCC(n\u2009=\u200918), premalignant lesions(PML) (n\u2009=\u20098) and normal control patients (n\u2009=\u200912). Their oral microbiome was sampled by oral wash and defined by 16S rRNA gene sequencing. We report that the periodontal pathogens\n                    <jats:italic>Fusobacterium, Prevotella, Alloprevotella<\/jats:italic>\n                    were enriched while commensal\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    depleted in OC\u2010SCC. Based on the four genera plus a marker genus\n                    <jats:italic>Veillonella<\/jats:italic>\n                    for PML, we classified the oral microbiome into two types. Gene\/pathway analysis revealed a progressive increase of genes encoding HSP90 and ligands for TLRs 1, 2 and 4 along the controls\u2192PML\u2009\u2192\u2009OC\u2010SCC progression sequence. Our findings suggest an association between periodontal pathogens and OC\u2010SCC in non smoking HPV negative patients.\n                  <\/jats:p>","DOI":"10.1002\/ijc.32152","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T04:27:10Z","timestamp":1548304030000},"page":"775-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-5426","authenticated-orcid":false,"given":"Ian","family":"Ganly","sequence":"first","affiliation":[{"name":"Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York 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