{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:52:52Z","timestamp":1792803172546,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PCC\u2010156725"],"award-info":[{"award-number":["PCC\u2010156725"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["34695"],"award-info":[{"award-number":["34695"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:p>We sought to determine if neonatal phototherapy is associated with a greater risk of childhood cancer. We conducted a retrospective cohort study of 786,998 infants born in hospitals of Quebec, Canada between 2006 and 2016, with 4,660,868 person\u2010years of follow\u2010up over an 11\u2010year period. The exposures were neonatal phototherapy (32,314 or 4.1% of infants) and untreated jaundice (91,855 or 11.7% of infants). The outcome was hospitalization for solid or hematopoietic childhood tumours between 2 months and 11\u2009years of age. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for the association of phototherapy with childhood cancer, adjusted for infant characteristics. The incidence of childhood cancer was higher for infants with phototherapy (25.1 per 100,000 person\u2010years) and untreated jaundice (23.0 per 100,000) compared to unexposed infants (21.6 per 100,000). Phototherapy appeared to be associated with late onset solid tumours, including brain\/central nervous system cancers. Between age 4 and 11\u2009years, children who received neonatal phototherapy had more than 2 times the risk of any solid tumour compared to unexposed children (HR 2.26, 95% CI 1.34\u20133.81). Results were similar for phototherapy compared against untreated jaundice. A similar trend was however less apparent for hematopoietic cancer. We conclude that neonatal phototherapy may be associated with a slightly increased risk of solid tumours in childhood, but cannot rule out an effect of bilirubin. Minimizing unnecessary exposure to phototherapy through adherence to recommended thresholds for treatment is encouraged.<\/jats:p>","DOI":"10.1002\/ijc.32158","type":"journal-article","created":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T14:04:18Z","timestamp":1548511458000},"page":"2061-2069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Neonatal phototherapy and future risk of childhood cancer"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0459","authenticated-orcid":false,"given":"Nathalie","family":"Auger","sequence":"first","affiliation":[{"name":"University of Montreal Hospital Research Centre  Montreal QC Canada"},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal QC Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Laverdi\u00e8re","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics Sainte\u2010Justine University Hospital Centre, University of Montreal  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimina","family":"Ayoub","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Research Centre  Montreal QC Canada"},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Lo","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal QC Canada"},{"name":"Department of Epidemiology, Biostatistics, and Occupational Health McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy Mai","family":"Luu","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics Sainte\u2010Justine University Hospital Centre, University of Montreal  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0708376"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.02.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmed-2016-110528"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12335"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00731.x"},{"key":"e_1_2_7_7_1","first-page":"441","article-title":"Prenatal and neonatal risk factors for childhood myeloid leukemia","volume":"4","author":"Cnattingius S","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052666"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.399"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1354"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1353"},{"key":"e_1_2_7_12_1","volume-title":"Childhood cancer survivorship: improving care and quality of life","author":"Hewitt M","year":"2003"},{"key":"e_1_2_7_13_1","volume-title":"Med\u2010Echo System Normative Framework\u2014Maintenance and use of data for the study of hospital clientele","author":"Ministry of Health and Social Services","year":"2017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/12.5.401"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2014.09.013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr470"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.34.1.03"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp107"},{"key":"e_1_2_7_20_1","unstructured":"SoY LinG JohnstonG. 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