{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T22:55:47Z","timestamp":1775775347066,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["NCT00301457"],"award-info":[{"award-number":["NCT00301457"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>The phase III DATA study investigates the efficacy of adjuvant anastrozole (6 <jats:italic>vs<\/jats:italic>. 3\u2009year) in postmenopausal women with breast cancer previously treated with 2\u20133\u2009years of tamoxifen. This planned side\u2010study assessed patterns of care regarding detection and treatment of osteopenia\/osteoporosis, and trends in bone mineral density (BMD) during and after therapy. We registered all BMD measurements and bisphosphonate\u2010use. Time to osteopenia\/osteoporosis was analysed by Kaplan Meier methodology. For the trend in <jats:italic>T<\/jats:italic>\u2010scores we used linear mixed models with random patients effects. Of 1860 eligible DATA patients, 910 (48.9%) had a baseline BMD measurement. Among patients with a normal baseline BMD (n\u2009=\u2009417), osteopenia was observed in 53.5% and 55.4% in the 6\u2010 and 3\u2010year group respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.18), during follow\u2010up. Only two patients (3\u2010year group) developed osteoporosis. Of the patients with osteopenia at baseline (n\u2009=\u2009408), 24.4% and 20.4% developed osteoporosis respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.89). Three years after randomisation 18.3% and 18.2% used bisphosphonates in the 6\u2010 and 3\u2010year groups respectively and 6 years after randomisation this was 23.7% and 20.9% respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.90) of which the majority used oral bisphosphonates. The yearly mean BMD\u2010change during anastrozole in the lumbar spine showed a <jats:italic>T<\/jats:italic>\u2010score decline of 0.075. After bisphosphonate addition the decline became less prominent (0.047 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001)) and after anastrozole cessation, while continuing bisphosphonates, the mean BMD yearly increased (0.047 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001)). In conclusion, extended anastrozole therapy was not associated with a higher incidence of osteoporosis. Anastrozole\u2010use was associated with a BMD decrease; however, the decline was modest and partially reversible after anastrozole cessation.<\/jats:p>","DOI":"10.1002\/ijc.32205","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T18:14:07Z","timestamp":1549995247000},"page":"1325-1333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment and management of bone health in women with early breast cancer receiving endocrine treatment in the DATA study"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-7364","authenticated-orcid":false,"given":"Irene E.G.","family":"van Hellemond","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, GROW \u2013 School for Oncology and Developmental Biology Maastricht University Medical Centre  Maastricht the 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Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice J.C.","family":"van der Sangen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Catharina Hospital  Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith R.","family":"Kroep","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiltje","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Medical Centre Leeuwarden  Leeuwarden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aafke H.","family":"Honkoop","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Isala Clinics  Zwolle the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans 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