{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:36Z","timestamp":1786977876207,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007505","name":"Kirsten og Freddy Johansens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["306088"],"award-info":[{"award-number":["306088"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n                    High mammographic density is a well\u2010known risk factor for breast cancer. This study aimed to search for a possible birth cohort effect on mammographic density, which might contribute to explain the increasing breast cancer incidence. We separately analyzed left and right breast density of Dutch women from a 13\u2010year period (2003\u20132016) in the breast cancer screening programme. First, we analyzed age\u2010specific changes in average percent dense volume (PDV) across birth cohorts. A linear regression analysis (PDV\n                    <jats:italic>vs<\/jats:italic>\n                    . year of birth) indicated a small but statistically significant increase in women of: 1) age 50 and born from 1952 to 1966 (left, slope\u2009= 0.04,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.003; right, slope\u2009= 0.09,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001); 2) age 55 and born from 1948 to 1961 (right, slope\u2009= 0.04,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01); and 3) age 70 and born from 1933 to 1946 (right, slope\u2009= 0.05,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). A decrease of total breast volume seemed to explain the increase in PDV. Second, we compared proportion of women with dense breast in women born in 1946\u20131953 and 1959\u20131966, and observed a statistical significant increase of proportion of highly dense breast in later born women, in the 51 to 55 age\u2010groups for the left breast (around a 20% increase in each age\u2010group), and in the 50 to 56 age\u2010groups for the right breast (increase ranging from 27% to 48%). The study indicated a slight increase in mammography density across birth cohorts, most pronounced for women in their early 50s, and more marked for the right than for the left breast.\n                  <\/jats:p>","DOI":"10.1002\/ijc.32210","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T05:25:35Z","timestamp":1550121935000},"page":"2954-2962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Change in mammographic density across birth cohorts of Dutch breast cancer screening participants"],"prefix":"10.1002","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-2599","authenticated-orcid":false,"given":"George","family":"Napolitano","sequence":"first","affiliation":[{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-5236","authenticated-orcid":false,"given":"Elsebeth","family":"Lynge","sequence":"additional","affiliation":[{"name":"Nyk\u00f8bing Falster Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lillholm","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Vejborg","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla H.","family":"van Gils","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health, Sciences and Primary Care University Medical Center Utrecht, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Computer Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Karssemeijer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University, Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"StewartBW WildCP.World cancer report 2014. Lyon France: International Agency for Research on Cancer 2014."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199207303270505"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2901-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1829"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920401)69:7 <1896::AID-CNCR2820691704>3.0.CO;2-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2647"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002335"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-409"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-13666-5_46"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085952"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"Comparing visually assessed BI\u2010RADS breast density and automated volumetric breast density software: a cross\u2010sectional study in a breast cancer screening setting","volume":"10","author":"Waal D","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185114554674"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00118-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.02.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.07.009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02742938"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.10.3201"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.4.629"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31818c046b"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_2_6_22_1","first-page":"419","article-title":"Breast cancer and hormone\u2010replacement therapy in the million women study","volume":"362","author":"Beral V","year":"2018","journal-title":"Lancet"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4446-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008926607428"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31818aefef"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81482-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000094395.59028.0F"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(78)90020-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0021932000003837"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.04.005"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.627"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0205-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2620"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2011.04.002"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1947.31"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051887"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3596"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.32210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.32210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:40:11Z","timestamp":1694176811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.32210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/ijc.32210"],"URL":"https:\/\/doi.org\/10.1002\/ijc.32210","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}