{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:07:03Z","timestamp":1790820423513,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,1,15]]},"abstract":"<jats:p>Cadmium, due to its estrogen\u2010like activity, has been suspected to increase the risk of breast cancer; however, epidemiological studies have reported inconsistent findings. We conducted a case\u2013control study (4,059 cases and 4,059 matched controls) nested within the E3N French cohort study to estimate the risk of breast cancer associated with long\u2010term exposure to airborne cadmium pollution, and its effect according to molecular subtype of breast cancer (estrogen receptor negative\/positive [ER\u2212\/ER+] and progesterone receptor negative\/positive [PR\u2212\/PR+]). Atmospheric exposure to cadmium was assessed using a Geographic Information System\u2010based metric, which included subject's residence\u2010to\u2010cadmium source distance, wind direction, exposure duration and stack height. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Overall, there was no significant association between cumulative dose of airborne cadmium exposure and the risk of overall, premenopausal and postmenopausal breast cancer. However, by ER and PR status, inverse associations were observed for ER\u2212 (OR<jats:sub>Q5 <jats:italic>vs<\/jats:italic>. Q1<\/jats:sub>\u2009=\u20090.63; 95% CI: 0.41\u20130.95, <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.043) and for ER\u2212\/PR\u2212 breast tumors (OR<jats:sub>Q4 <jats:italic>vs<\/jats:italic>. Q1<\/jats:sub>\u2009=\u20090.62; 95% CI: 0.40\u20130.95, OR<jats:sub>Q5 <jats:italic>vs<\/jats:italic>. Q1<\/jats:sub>\u2009=\u20090.68; 95% CI: 0.42\u20131.07, <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.088). Our study provides no evidence of an association between exposure to cadmium and risk of breast cancer overall but suggests that cadmium might be related to a decreased risk of ER\u2212 and ER\u2212\/PR\u2212 breast tumors. These observations and other possible effects linked to hormone receptor status warrant further investigations.<\/jats:p>","DOI":"10.1002\/ijc.32257","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T15:23:52Z","timestamp":1552145032000},"page":"341-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Chronic long\u2010term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort"],"prefix":"10.1002","volume":"146","author":[{"given":"Amina","family":"Amadou","sequence":"first","affiliation":[{"name":"Department of Cancer and Environment Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Inserm UA 08 Radiations: D\u00e9fense, Sant\u00e9, Environnement  69008 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Praud","sequence":"additional","affiliation":[{"name":"Department of Cancer and Environment Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Inserm U1052, CNRS UMR5286 Universit\u00e9 Claude Bernard Lyon 1, Cancer Research Center of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Coudon","sequence":"additional","affiliation":[{"name":"Department of Cancer and Environment Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Ecole Centrale de Lyon, INSA Lyon Universit\u00e9 Claude Bernard Lyon 1  Ecully France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie M.N.","family":"Danjou","sequence":"additional","affiliation":[{"name":"Section of Environment and Radiation International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Faure","sequence":"additional","affiliation":[{"name":"Department of Cancer and Environment Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Leffondr\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux, ISPED Centre Inserm U1219 Bordeaux Population Health  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Le Romancer","sequence":"additional","affiliation":[{"name":"Inserm U1052, CNRS UMR5286 Universit\u00e9 Claude Bernard Lyon 1, Cancer Research Center of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Severi","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP, Inserm U1018), Facult\u00e9s de M\u00e9decine Universit\u00e9 Paris\u2010Saclay, UPS UVSQ, Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Salizzoni","sequence":"additional","affiliation":[{"name":"Ecole Centrale de Lyon, INSA Lyon Universit\u00e9 Claude Bernard Lyon 1  Ecully France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-3869","authenticated-orcid":false,"given":"Francesca Romana","family":"Mancini","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations (CESP, Inserm U1018), Facult\u00e9s de M\u00e9decine Universit\u00e9 Paris\u2010Saclay, UPS UVSQ, Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Fervers","sequence":"additional","affiliation":[{"name":"Department of Cancer and Environment Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Inserm UA 08 Radiations: D\u00e9fense, Sant\u00e9, Environnement  69008 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31679-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30505-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70487-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0535"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0827-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-009-9273-2"},{"key":"e_1_2_7_8_1","first-page":"317","volume-title":"Guidelines for drinking\u2010water quality, 3rd edition incorporating 1st and 2nd addenda. Vol. 1. Recommendations","author":"WHO","year":"2008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70134-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100226"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2414-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2016.04.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv085"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw204"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv285"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.10.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.892743"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075087"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0735"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000277"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu184"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2002394"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9942-z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.11.027"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-019-0446-x"},{"key":"e_1_2_7_26_1","unstructured":"AndreJM BouchardD DruartA et al. CITEPA. Rapport OMINEA (Organisation et m\u00e9thodes des inventaires nationaux des \u00e9missions atmosph\u00e9riques en France) \u2013 15\u00e8me edition. 2018; Available from:https:\/\/www.citepa.org\/images\/III-1_Rapports_Inventaires\/OMINEA\/OMINEA_2018.pdf"},{"key":"e_1_2_7_27_1","unstructured":"EMEP\/EEA. EMEP\/EEA air pollutant emission inventory guidebook.2013; Available from:https:\/\/www.eea.europa.eu\/publications\/emep-eea-guidebook-2013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-017-0217-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2017.08.034"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.01.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6793"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780080504"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.08.014"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2013.03.010"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2918-6"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-013-9273-9"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-009-9268-6"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.12.017"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm902"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2008.04.002"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2010.10.001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.v28.i1.90"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16572"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1139\/O09-018"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-015-3830-9"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2016.07.002"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr256"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.13141"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31821d0879"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2015.03.019"}],"updated-by":[{"DOI":"10.1002\/ijc.32873","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000}}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.32257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.32257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T09:50:26Z","timestamp":1694253026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.32257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1,15]]}},"alternative-id":["10.1002\/ijc.32257"],"URL":"https:\/\/doi.org\/10.1002\/ijc.32257","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1002\/ijc.32873","asserted-by":"object"}]},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2019-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}