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One hundred ninety\u2010eight Chinese EC patients were screened for germline mutations in a panel of cancer susceptibility genes using next\u2010generation sequencing combined with multiplex ligation\u2010dependent probe amplification. First, we found that among patients under 50\u2009years of age, 26% (18\/69) carried germline genetic mutations, all involving mismatch repair (MMR) genes except for one mutation affecting <jats:italic>BRCA1<\/jats:italic>. Second, when we focused on Lynch syndrome (LS) with additional selected patients, 45 were identified to carry pathogenic mutations in MMR genes, with a higher frequency found in <jats:italic>MSH2<\/jats:italic> and <jats:italic>MSH6<\/jats:italic>. We found that age at onset, personal and familial history together with immunohistochemical assay results were the most useful criteria for the diagnosis of LS although limitations in routine practice and the sensitivity and specificity of each parameter should be taken into account. One pathogenic mutation in the <jats:italic>PALB2<\/jats:italic> gene was detected in a patient with no breast cancer in her family. Interestingly, we identified a family carrying pathogenic variant in both <jats:italic>PMS2<\/jats:italic> and <jats:italic>BRCA1<\/jats:italic> genes with distinct clinical phenotypes. Multigene panel testing should be recommended to patients based on their clinical information and tumor phenotype. Our study also showed the genetic complexity in EC, which requires further investigations.<\/jats:p>","DOI":"10.1002\/ijc.32389","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T14:23:11Z","timestamp":1557152591000},"page":"1290-1298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Screening for hereditary cancers in patients with endometrial cancer reveals a high frequency of germline mutations in cancer predisposition genes"],"prefix":"10.1002","volume":"145","author":[{"given":"Wenjuan","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"},{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Topgen Bio\u2010Pharm Co, Ltd.  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