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Merkel cell polyomavirus (MCPyV) T\u2010antigens are expressed and involved in the pathogenesis of a large proportion of Merkel cell carcinoma (MCC). Yet, how MCPyV induces tumorigenesis is not fully understood. Herein, we show that MCPyV T\u2010antigens induce\n                    <jats:italic>miR\u2010375<\/jats:italic>\n                    ,\n                    <jats:italic>miR\u201030a\u20103p<\/jats:italic>\n                    and\n                    <jats:italic>miR\u201030a\u20105p<\/jats:italic>\n                    expressions, which target multiple key genes involved in autophagy, including\n                    <jats:italic>ATG7<\/jats:italic>\n                    ,\n                    <jats:italic>SQSTM1<\/jats:italic>\n                    (p62) and\n                    <jats:italic>BECN1<\/jats:italic>\n                    . In MCC tumors, low expression of ATG7 and p62 are associated with MCPyV\u2010positive tumors. Ectopic expression of MCPyV small T\u2010antigen and truncated large T\u2010antigen (LT), but not the wild\u2010type LT, resulted in autophagy suppression, suggesting the importance of autophagy evasion in MCPyV\u2010mediated tumorigenesis. Torin\u20101 treatment induced cell death, which was attenuated by autophagy inhibitor, but not pan\u2010caspase inhibitor, suggesting a potential role of autophagy in promoting cell death in MCC. Conceptually, our study shows that MCPyV oncoproteins suppress autophagy to protect cancer cells from cell death, which contribute to a better understanding of MCPyV\u2010mediated tumorigenesis and potential MCC treatment.\n                  <\/jats:p>","DOI":"10.1002\/ijc.32503","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T09:39:05Z","timestamp":1560159545000},"page":"1652-1666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes"],"prefix":"10.1002","volume":"146","author":[{"given":"Satendra","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet; Cancer Center Karolinska, Karolinska University Hospital  Stockholm 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