{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:11:14Z","timestamp":1761808274418,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["6110\u201000596B"],"award-info":[{"award-number":["6110\u201000596B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:p>Head and neck cancer (HNC) is the sixth most frequent malignancy with high mortality and substantial morbidity and hence there is a need for identification of preventive factors. Preclinical and observational studies have reported antineoplastic effects of nonaspirin nonsteroidal anti\u2010inflammatory drugs (NSAIDs), but studies of nonaspirin NSAID use and risk of HNC are sparse and with inconsistent results. We therefore conducted a register\u2010based case\u2013control study nested in the entire Danish population. Cases (<jats:italic>n<\/jats:italic> = 12,389) comprised all Danish residents aged 30\u201384\u2009years with a histologically verified primary HNC diagnosis during 2000\u20132015. Based on the literature, cases were categorized into four groups of anticipated association with human papillomavirus (HPV): strong, potential, no\/weak and uncertain. Age\u2010 and sex\u2010matched population controls (<jats:italic>n<\/jats:italic> = 185,835) were selected by risk\u2010set\u2010sampling. We obtained information on filled prescriptions of nonaspirin NSAIDs, other drug use, comorbid conditions and socioeconomic parameters from nationwide Danish registries. Ever\u2010use (\u22652 prescriptions) of nonaspirin NSAIDs was not associated with the overall risk of HNC after adjustment for potential confounders (odds ratio [OR]: 0.99, 95% confidence interval [CI]: 0.95\u20131.03). However, long\u2010term consistent use (\u22655 years) was associated with a 25% reduction in HNC risk (OR: 0.75, 95% CI: 0.62\u20130.90). Stratified analyses by anticipated HPV\u2010association showed no material differences in estimates. In conclusion, ever\u2010use of nonaspirin NSAIDs was not associated with the risk of HNC with no apparent influence on the estimates by the anticipated HPV\u2010association. However, long\u2010term consistent use may be associated with a reduced risk of HNC and merits further investigation.<\/jats:p>","DOI":"10.1002\/ijc.32544","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T15:48:06Z","timestamp":1562082486000},"page":"2139-2146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of nonaspirin nonsteroidal anti\u2010inflammatory drugs and risk of head and neck cancer: A nationwide case\u2013control study"],"prefix":"10.1002","volume":"146","author":[{"given":"Cecilie D.","family":"de la Cour","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen 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