{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:09:18Z","timestamp":1773011358784,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA55075"],"award-info":[{"award-number":["P01 CA55075"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA87969"],"award-info":[{"award-number":["P01 CA87969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA151993"],"award-info":[{"award-number":["R01 CA151993"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 CA223619"],"award-info":[{"award-number":["R03 CA223619"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 CA197735"],"award-info":[{"award-number":["R35 CA197735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA167552"],"award-info":[{"award-number":["UM1 CA167552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA167552"],"award-info":[{"award-number":["U01 CA167552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006535","name":"Entertainment Industry Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006535","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Anthropometric measurements, such as body mass index (BMI), waist circumference, and body fat percentage, have been used as indicators of obesity. Despite evidence that excess body fat is a risk factor for colorectal carcinoma (CRC), the magnitude of the association of BMI and other obesity indicators with the long\u2010term risk of CRC remains unclear. Utilizing a Cox proportional hazards regression model, we examined differential associations between predicted body fat percentage and BMI with the risk of CRC (<jats:italic>n<\/jats:italic> = 2,017). The associations between CRC incidence and different adiposity measurements were also assessed. Predicted body fat percentage had a similar increased risk of CRC risk as BMI. In multivariable\u2010adjusted analyses, the hazard ratio for CRC in the second to fifth quintiles (compared to the first quintile) of predicted body fat percentage were 1.32, 1.31, 1.53 and 2.09 for men (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009&lt;\u20090.001) and 0.91, 0.90, 0.98 and 1.15 for women (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.03). Among various anthropometric measurements, predicted fat mass and waist circumference were slightly more strongly associated with CRC risk than BMI. In conclusion, the novel anthropometric prediction equations provided further evidence that a greater amount of body fat might contribute to CRC risk in both sexes. An innovative approach enabled us to estimate the susceptibilities of specific body composition with CRC risk, in an inexpensive and minimally invasive manner. Furthermore, the typically used measures of BMI and waist circumference are robust measures of adiposity to predict cancer risk in a relatively healthy population.<\/jats:p>","DOI":"10.1002\/ijc.32553","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T16:04:48Z","timestamp":1562342688000},"page":"2383-2393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010term status of predicted body fat percentage, body mass index and other anthropometric factors with risk of colorectal carcinoma: Two large prospective cohort studies in the US"],"prefix":"10.1002","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-9550","authenticated-orcid":false,"given":"Akiko","family":"Hanyuda","sequence":"first","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health  Boston MA"},{"name":"Epidemiology and Prevention Group, Center for Public Health Sciences National Cancer Center  Tokyo Japan"},{"name":"Department of Ophthalmology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-4637","authenticated-orcid":false,"given":"Dong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Ogino","sequence":"additional","affiliation":[{"name":"Program in MPE Molecular Pathological Epidemiology, Department of Pathology Brigham and Women's Hospital  Boston MA"},{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute and Harvard Medical School  Boston MA"},{"name":"Department of Oncologic Pathology Dana\u2010Farber Cancer Institute  Boston MA"},{"name":"Broad Institute of MIT and Harvard  Cambridge MA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward L.","family":"Giovannucci","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard T.H. Chan School of Public Health  Boston MA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston MA"},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800541"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.39"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61744-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1606602"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2016.02.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00031.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.3.475"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.553.13.4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21508"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0199-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17997-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10842"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802606"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj246"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.106"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517002665"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90542-W"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.1997.6.49"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199011000-00009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0433-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2575"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780080504"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02294359"},{"key":"e_1_2_8_26_1","volume-title":"Food, nutrition, physical activity, and the prevention of cancer: a Global perspective [second report]","author":"World Cancer Research Fund\/American Institute for Cancer Research","year":"2007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0883"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv177"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-016-0831-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.113905"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.045815"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-082117-051723"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-23"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32830b5f23"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.1.74"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X05003454"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.241"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803230"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0353"},{"key":"e_1_2_8_40_1","volume-title":"Diet, nutrition, physical activity and colorectal cancer. Continuous Update Project","author":"World Cancer Research Fund\/ American Institute of Cancer Research (WCRF\/AICR)","year":"2018"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000252"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4913-5"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0038-1"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9141-x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.14.2117"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00613.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304701"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.383"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.11.012"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4280"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.32553","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:19:01Z","timestamp":1693826341000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.32553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/ijc.32553"],"URL":"https:\/\/doi.org\/10.1002\/ijc.32553","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"assertion":[{"value":"2019-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}