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Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic pollutants that exist widely in the environment. We hypothesized that PAHs exposure was related to the progression of cervical cancer, and could increase the effect of HR\u2010HPV on CIN. We investigated the effects of PAHs exposure combined with HR\u2010HPV infection on CIN in community population in Shanxi Province, China. A total of 2,285 women were enrolled into the study. HR\u2010HPV genotypes were detected by flow\u2010through hybridization technology. 1\u2010hydroxypyrene (1\u2010OHP) was detected by high\u2010performance liquid chromatography. The top three HR\u2010HPV genotypes were 16, 58 and 52 in turn. With unconditional logistic regression analysis, we found that HR\u2010HPV infection (adjusted odds ratio [aOR] = 4.08, 95% confidence interval [CI]: 3.00\u20135.54), HPV16 infection (aOR = 4.71, 95% CI: 3.39\u20136.53), HPV58 infection (aOR = 2.29, 95% CI: 1.41\u20133.73) and PAHs high exposure (aOR = 2.57, 95% CI: 1.82\u20133.62) increased the risk of CIN2\/3, showing an increasing trend (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with the severity of cervical lesions. Compared to Q1 (&lt;0.06\u2009\u03bcmol\/molCr) levels of 1\u2010OHP, women with Q4 (&gt;0.11\u2009\u03bcmol\/molCr) had a higher risk for CIN2\/3 (aOR = 7.68, 95% CI: 4.83\u201312.22). Additionally, we observed that there was a synergic effect between high exposure to PAHs and HR\u2010HPV infection in CIN2\/3. Furthermore, the results from the generalized multifactor dimensionality reduction model showed that there were joint interactions of PAHs, HPV16, HPV58 and HPV52 on the risk of CIN2\/3. Our study revealed that high exposure to PAHs could increase the risk for CIN, and it posed stronger risk when combined with HR\u2010HPV infection.<\/jats:p>","DOI":"10.1002\/ijc.32562","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T07:35:18Z","timestamp":1562744118000},"page":"2406-2412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of exposure to polycyclic aromatic hydrocarbons combined with high\u2010risk human papillomavirus infection on cervical intraepithelial neoplasia: A population study in Shanxi Province, China"],"prefix":"10.1002","volume":"146","author":[{"given":"Xiaoxue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health, Shanxi Medical University  Taiyuan 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