{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:01:06Z","timestamp":1787238066904,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>\n                    In this registry\u2010based cohort study, we estimated the risk of human papillomavirus (HPV)\u2010related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first\u2010time RTRs in Denmark during 1990\u20132015 in a nationwide nephrology register. For each RTR, we randomly selected 50 age\u2010 and sex\u2010matched non\u2010RTRs from the background population. The study population was followed for diagnoses of cervical, vaginal, vulvar, penile and anal intraepithelial neoplasia grades 2\u20133 (IN2\/3) and cancer for up to 27\u2009years. We estimated hazard ratios (HRs) of anogenital IN2\/3 and cancer in RTRs\n                    <jats:italic>vs<\/jats:italic>\n                    . non\u2010RTRs by Cox regression separately for men and women using age as underlying timescale, adjusting for income, education, HPV vaccination and immunocompromising conditions. We included 4,261 RTRs and 213,673 non\u2010RTRs. RTRs had increased hazard of cervical (HR = 2.1, 95% CI: 1.7\u20132.8), vaginal (HR = 35.0, 95% CI: 13.9\u201387.7), vulvar (HR = 16.4, 95% CI: 10.4\u201325.8), penile (HR = 21.9, 95% CI: 11.1\u201343.5) and anal (women: HR = 51.1, 95% CI: 28.0\u201393.1; men: HR = 39.0, 95% CI: 16.7\u201391.1) IN2\/3. The HRs of anogenital cancers were also increased at most sites. The HR of anogenital IN2\/3 in female RTRs tended to be higher during graft function than during dialysis. In female RTRs aged &lt;40\u2009years at transplantation, 10\u201315% had cervical IN2\/3 and 5\u201312% had vaginal\/vulvar\/anal IN2\/3 within 20\u2009years after transplantation, compared to 4\u20138 and 0.2\u20130.4%, respectively, of female non\u2010RTRs. In conclusion, RTRs had substantially higher risk of HPV\u2010related anogenital premalignancies and cancer than non\u2010RTRs.\n                  <\/jats:p>","DOI":"10.1002\/ijc.32565","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T12:09:50Z","timestamp":1562760590000},"page":"2413-2422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Human papillomavirus\u2010related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry\u2010based cohort study"],"prefix":"10.1002","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-9665","authenticated-orcid":false,"given":"Kristian","family":"Reinholdt","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise T.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-4565","authenticated-orcid":false,"given":"Christian","family":"Dehlendorff","sequence":"additional","affiliation":[{"name":"Unit of Statistics and Pharmacoepidemiology Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle K.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Department of Dermato\u2010Venerology Bispebjerg Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren S.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"H\u00e6dersdal","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venerology Bispebjerg Hospital, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Department of Gynecology, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Newsletter Transplant. 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