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It is well established that women with HIV have a higher risk of persistent HPV infection leading to cervical cancer. We assessed HPV prevalence and genotype distribution in 126 tissue specimens from confirmed invasive cervical cancer cases using Abbott real\u2010time PCR assay. Overall, 88 (69.8%) women were HIV\u2010infected. Fifty\u2010seven (64.8%) of the HIV\u2010infected women had a baseline CD4<jats:sup>+<\/jats:sup> count \u2265350 cells\/\u03bcl, and 82 (93.2%) were on antiretroviral therapy at the time of cervical cancer diagnosis. The median age of HIV\u2010infected patients was significantly younger than that of HIV\u2010uninfected patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). HPV DNA was detected in all of 126 (100%) of tissues analyzed in our study. The HPV genotypes identified included the HPV\u201016 (75.4%), HPV\u201018 (28.6%) and <jats:italic>other<\/jats:italic> high\u2010risk (hr) HPV genotypes (16.7%). HIV infection was positively associated with the presence of the HPV\u201016 genotype (<jats:italic>p<\/jats:italic> = 0.036), but not with HPV\u201018 or with <jats:italic>other<\/jats:italic> high\u2010risk (hr)\u2010HPV genotypes. Thirty\u2010three percent of the patients had multiple hr\u2010HPV genotypes, with higher rates in HIV\u2010infected women. These results highlight the importance and potential impact of large\u2010scale HPV vaccination programs covering HPV\u201016 and HPV\u201018 genotypes in countries like Botswana with high burden of HIV infection.<\/jats:p>","DOI":"10.1002\/ijc.32581","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T11:39:10Z","timestamp":1563622750000},"page":"1667-1673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Human papillomavirus genotypes in women with invasive cervical cancer with and without human immunodeficiency virus infection in Botswana"],"prefix":"10.1002","volume":"146","author":[{"given":"Leabaneng","family":"Tawe","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, Faculty of Health Sciences University of Botswana  Gaborone Botswana"},{"name":"Botswana Harvard AIDS Institute Partnership  Gaborone Botswana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"MacDuffie","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School of Brown University  Providence RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Narasimhamurthy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine University of Botswana  Gaborone Botswana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Sue &amp; Bill Gross School of Nursing University of California Irvine  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simani","family":"Gaseitsiwe","sequence":"additional","affiliation":[{"name":"Botswana Harvard AIDS Institute Partnership  Gaborone Botswana"},{"name":"Department of Immunology and Infectious Diseases Harvard School of Public Health  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikhulile","family":"Moyo","sequence":"additional","affiliation":[{"name":"Botswana Harvard AIDS Institute Partnership  Gaborone Botswana"},{"name":"Department of Immunology and Infectious Diseases Harvard School of Public Health  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishmael","family":"Kasvosve","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, Faculty of Health Sciences University of Botswana  Gaborone Botswana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghyuk S.","family":"Shin","sequence":"additional","affiliation":[{"name":"Sue &amp; Bill Gross School of Nursing University of California Irvine  Irvine CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola M.","family":"Zetola","sequence":"additional","affiliation":[{"name":"Botswana\u2010University of Pennsylvania Partnership  Gaborone Botswana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo M.","family":"Paganotti","sequence":"additional","affiliation":[{"name":"Botswana\u2010University of Pennsylvania Partnership  Gaborone Botswana"},{"name":"Department of Biomedical Sciences, Faculty of Medicine University of Botswana  Gaborone Botswana"},{"name":"Department of Medicine, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-5937","authenticated-orcid":false,"given":"Surbhi","family":"Grover","sequence":"additional","affiliation":[{"name":"Botswana\u2010University of Pennsylvania Partnership  Gaborone Botswana"},{"name":"Department of Radiation Oncology, Perelman School of Medicine University of Pennsylvania  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.02.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-013-0479-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-817-1_12"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24075"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"S3\/35","article-title":"Burden and management of noncancerous HPV\u2010related conditions: HPV\u20106\/11 disease","volume":"24","author":"Lacey CJN","year":"2006","journal-title":"Vaccine"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_9_11_1","unstructured":"UNAIDS. 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