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Our aim was to evaluate the association between intakes of total, classes and subclasses of polyphenols and risk of differentiated TC and its main subtypes, papillary and follicular, in a European population. The European Prospective Investigation into Cancer and Nutrition cohort included 476,108 men and women from 10 European countries. During a mean follow\u2010up of 14\u2009years, there were 748 incident differentiated TC cases, including 601 papillary and 109 follicular tumors. Polyphenol intake was estimated at baseline using validated center\/country\u2010specific dietary questionnaires and the Phenol\u2010Explorer database. In multivariable\u2010adjusted Cox regression models, no association between total polyphenol and the risks of overall differentiated TC (HR<jats:sub>Q4 <jats:italic>vs<\/jats:italic>. Q1<\/jats:sub> = 0.99, 95% confidence interval [CI] 0.77\u20131.29), papillary (HR<jats:sub>Q4 <jats:italic>vs<\/jats:italic>. Q1<\/jats:sub> = 1.06, 95% CI 0.80\u20131.41) or follicular TC (HR<jats:sub>Q4 <jats:italic>vs<\/jats:italic>. Q1<\/jats:sub> = 1.10, 95% CI 0.55\u20132.22) were found. No associations were observed either for flavonoids, phenolic acids or the rest of classes and subclasses of polyphenols. After stratification by body mass index (BMI), an inverse association between the intake of polyphenols (<jats:italic>p<\/jats:italic>\u2010trend = 0.019) and phenolic acids (<jats:italic>p<\/jats:italic>\u2010trend = 0.007) and differentiated TC risk in subjects with BMI\u2009\u2265\u200925 was observed. In conclusion, our study showed no associations between dietary polyphenol intake and differentiated TC risk; although further studies are warranted to investigate the potential protective associations in overweight and obese individuals.<\/jats:p>","DOI":"10.1002\/ijc.32589","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T08:18:26Z","timestamp":1564042706000},"page":"1841-1850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort"],"prefix":"10.1002","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-6804","authenticated-orcid":false,"given":"Raul","family":"Zamora\u2010Ros","sequence":"first","affiliation":[{"name":"Unit of Nutrition and Cancer, Cancer Epidemiology Research Program Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Cayssials","sequence":"additional","affiliation":[{"name":"Unit of Nutrition and Cancer, Cancer Epidemiology Research Program Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"Departamento de Bioestad\u00edstica Facultad de Veterinaria, Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Franceschi","sequence":"additional","affiliation":[{"name":"CRO Aviano National Cancer Institute IRCCS  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-8960","authenticated-orcid":false,"given":"Cecilie","family":"Kyr\u00f8","sequence":"additional","affiliation":[{"name":"Unit of Diet, Genes and Environment Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2237-0128","authenticated-orcid":false,"given":"Elisabete","family":"Weiderpass","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Hennings","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sandstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department for Radiation Sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[{"name":"Unit of Diet, Genes and Environment Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Olsen","sequence":"additional","affiliation":[{"name":"Unit of Diet, Genes and Environment Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Overvad","sequence":"additional","affiliation":[{"name":"Department of Public Health Section for Epidemiology, Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-5693","authenticated-orcid":false,"given":"Marie\u2010Christine","family":"Boutron\u2010Ruault","sequence":"additional","affiliation":[{"name":"CESP, Fac. de m\u00e9decine \u2010 Univ. 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