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Based on targeted\u2010capture sequencing, we retrospectively analyzed the correlation between EMMs and prognosis in 83 IR\u2010AML patients treated with decitabine in combination with cytarabine, aclarubicin hydrochloride and granulocyte colony\u2010stimulating factor (DCAG, <jats:italic>n<\/jats:italic> = 35) or \u201c7\u2009+\u20093\u201d induction regimens (<jats:italic>n<\/jats:italic> = 48). In the multivariate analyses, EMM (+) patients did not show any statistically significant difference in remission rates from EMM (\u2212) patients in the DCAG group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), but achieved inferior complete remission (CR; <jats:italic>p<\/jats:italic> = 0.03) and overall remission rates (ORR; <jats:italic>p<\/jats:italic> = 0.04) after the first course of standard induction regimens (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In the EMM (\u2212) cohort, the DCAG group showed the tendency of adverse total CR (<jats:italic>p<\/jats:italic> = 0.06). Besides, DCAG group with EMMs achieved the best survival outcome independent of baseline characteristics, whereas it was opposite in EMM (+) patients receiving standard induction regimens (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, in the EMM (+) cohort, the survival rate of isolated DCAG group was statistically similar to that of the combination of standard chemotherapies and allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.40), whereas patients who received only standard regimens had the worst survival rate (0.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). It can be concluded that the EMMs might be regarded as the potentially predictive biomarkers of better response to DCAG in IR\u2010AML patients.<\/jats:p>","DOI":"10.1002\/ijc.32593","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T17:08:54Z","timestamp":1564074534000},"page":"1457-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Epigenetic modifier gene mutations\u2010positive AML patients with intermediate\u2010risk karyotypes benefit from decitabine with CAG regimen"],"prefix":"10.1002","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-4454","authenticated-orcid":false,"given":"Qingyu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Hematology and BMT center Chinese PLA General Hospital  Beijing 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