{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:49:12Z","timestamp":1790254152472,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:p>Many long intergenic noncoding RNAs (lincRNAs) serve as cancer biomarkers for diagnosis or prognostication. To understand the role of lincRNAs in the rare neuroendocrine tumors pheochromocytoma and paraganglioma (PCPG), we performed first time in\u2010depth characterization of lincRNA expression profiles and correlated findings to clinical outcomes of the disease. RNA\u2010Seq data from patients with PCPGs and 17 other tumor types from The Cancer Genome Atlas and other published sources were obtained. Differential expression analysis and a machine\u2010learning model were used to identify transcripts specific to PCPGs, as well as established PCPG molecular subtypes. Similarly, lincRNAs specific to aggressive PCPGs were identified, and univariate and multivariate analysis was performed for metastasis\u2010free survival. The results were validated in independent samples using RT\u2010PCR. From a pan\u2010cancer context, PCPGs had a specific and unique lincRNA profile. Among PCPGs, five different molecular subtypes were identified corresponding to the established molecular classification. Upregulation of 13 lincRNAs was found to be associated with aggressive\/metastatic PCPGs. RT\u2010PCR validation confirmed the overexpression of four lincRNAs in metastatic compared to non\u2010metastatic PCPGs. Kaplan\u2013Meier analysis identified five lincRNAs as prognostic markers for metastasis\u2010free survival of patients in three subtypes of PCPGs. Stratification of PCPG patients with a risk\u2010score formulated using multivariate analysis of lincRNA expression profiles, presence of key driver mutations, tumor location, and hormone secretion profiles showed significant differences in metastasis\u2010free survival. PCPGs thus exhibit a specific lincRNA expression profile that also corresponds to the established molecular subgroups and can be potential marker for the aggressive\/metastatic PCPGs.<\/jats:p>","DOI":"10.1002\/ijc.32654","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T15:30:41Z","timestamp":1567179041000},"page":"2326-2335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long intergenic noncoding RNA profiles of pheochromocytoma and paraganglioma: A novel prognostic biomarker"],"prefix":"10.1002","volume":"146","author":[{"given":"Suman","family":"Ghosal","sequence":"first","affiliation":[{"name":"Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health  Bethesda 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