{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:31:48Z","timestamp":1790069508201,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Calretinin (CRT) is a calcium\u2010binding protein that controls intracellular calcium signaling. Besides its prominent expression in neurons, serum CRT (sCRT) has recently been suggested as blood\u2010based biomarker for prediagnostic mesothelioma detection. CRT is expressed in ovarian cancer tissues in up to 40% of cases; however, its clinical relevance as blood\u2010based biomarker for ovarian cancer is unknown. sCRT was determined by calretinin enzyme\u2010linked immunoabsorbent assay (Calretinin\u2010ELISA, DLD Diagnostika GmbH, Hamburg, Germany) in a total of 515 serum samples from 116 healthy controls and 134 ovarian cancer patients (thereof 86% with <jats:italic>F\u00e9d\u00e9ration Internationale de Gyn\u00e9cologie et d'Obst\u00e9trique<\/jats:italic> [FIGO] III\/IV), including samples at primary diagnosis and at four longitudinal follow\u2010up time points in the course of treatment and at recurrence. sCRT level was significantly increased in ovarian cancer patients compared to healthy controls (estimated difference = 0.3 ng\/ml, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), was mostly independent from CA125 (<jats:italic>r<\/jats:italic>\u2009\u2264\u20090.388) and enabled accurate discrimination between cases and controls (area under the curve = 0.85). Higher sCRT level at primary diagnosis predicted suboptimal debulking (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and was associated with advanced FIGO\u2010stage (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and increased amount of ascites (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). sCRT levels at primary diagnosis and its dynamics in the course of chemotherapy were independent predictors for poor progression\u2010free survival (hazard ratio [HR] = 1.99, confidence interval [CI] = [1.13\u20133.52], <jats:italic>p<\/jats:italic> = 0.0181) and overall survival (HR = 15.4, CI = [1.92\u2013124], <jats:italic>p<\/jats:italic> = 0.0099). Furthermore, sCRT at primary diagnosis or a relative sCRT increase in the time interval between surgery and the onset of chemotherapy were both independent predictors of platinum resistance (OR = 4.99, CI = [3.50\u201316,001], <jats:italic>p<\/jats:italic> = 0.0016; OR = 2.41, CI = [1.37\u20136,026], <jats:italic>p<\/jats:italic> = 0.0271, respectively). This is the first study that suggests sCRT as liquid biopsy marker for independent prediction of platinum resistance and prognosis.<\/jats:p>","DOI":"10.1002\/ijc.32676","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T16:04:22Z","timestamp":1568217862000},"page":"2608-2618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum calretinin as an independent predictor for platinum resistance and prognosis in ovarian cancer"],"prefix":"10.1002","volume":"146","author":[{"given":"Theresa","family":"Link","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Passek","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Wimberger","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Frank","sequence":"additional","affiliation":[{"name":"DRK\u2010Blood Donor Service, ITM Plauen  Plauen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana Damyanova","family":"Vassileva","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany Helmholtz\u2010Zentrum Dresden\u2010Rossendorf (HZDR)  Dresden Germany"},{"name":"German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kramer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Medical Faculty and University Hospital, Technische Universit\u00e4t Dresden  Dresden 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