{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:55:57Z","timestamp":1789181757382,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Modern cancer therapy has led to a growing number of pediatric and young adult cancer survivors, who are prone to increased morbidities caused by the late effects of therapy. The aim of our study was to investigate pediatric and young adult cancer survivors' morbidity due to renal and bone metabolism diseases and especially to study bone metabolism in cancer survivors with renal disease. Patients were identified from the Finnish Cancer Registry, and the cohort consisted of 13,860, 5\u2010year survivors of cancer diagnosed below the age of 35\u2009years. Healthy siblings were used as the comparison cohort. Information on the main outcomes was linked from the national Care Register for Health Care. Hazard ratios (HRs) comparing cancer survivors to siblings were calculated for various outcomes. The patient cohort was separated into two age groups, pediatric (0\u201319\u2009years) and young adults (20\u201334\u2009years). Significantly elevated HRs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) in survivors were observed in both age groups for scoliosis (HR 1.6, 95% confidence interval [CI] 1.3\u20132.0), osteoporosis (HR 5.2, 95% CI 2.4\u201311.4), osteonecrosis (HR 12.7, 95% CI 5.4\u201329.7), nephritis (HR 1.9, 95% CI 1.5\u20132.2) and kidney failure (HR 3.6, 95% CI 2.4\u20135.3) for all. For cancer survivors with a renal outcome, the risk for developing any outcome of bone metabolism was increased (HR 2.3, 95% CI 1.4\u20133.6). These results show that pediatric and young adult cancer survivors have an elevated risk for long\u2010term, adverse outcomes related to renal function and bone metabolism. These results suggest follow\u2010up care for young cancer patients.<\/jats:p>","DOI":"10.1002\/ijc.32687","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T05:25:33Z","timestamp":1568611533000},"page":"1324-1332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diseases of renal function and bone metabolism after treatment for early onset cancer: A registry\u2010based study"],"prefix":"10.1002","volume":"146","author":[{"given":"Niilo","family":"Liuhto","sequence":"first","affiliation":[{"name":"University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5729-0059","authenticated-orcid":false,"given":"Marika H.","family":"Gr\u00f6nroos","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Turku University Hospital  Turku 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