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We previously identified a novel long noncoding RNA (lncRNA, TC0101441) in epithelial ovarian cancer (EOC) using microarrays. However, the impact of TC0101441 on EOC metastasis and prognosis remains unclear. TC0101441 expression in EOC tissues and its correlation with clinicopathological factors and prognosis were examined. A series of <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> assays were performed to elucidate the roles and mechanism of TC0101441 in EOC metastasis. We found that TC0101441 levels were elevated in EOC tissues compared with those in normal controls and significantly correlated with an advanced clinical stage and lymph node metastasis. TC0101441 was determined to be an independent prognostic predictor of overall survival (OS) and disease\u2010free survival (DFS). Furthermore, loss\u2010of\u2010function assays showed that TC0101441 promoted the invasive and metastatic capacities of EOC cells both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Mechanistically, the prometastatic effects of TC0101441 were linked to the induction of epithelial\u2013mesenchymal transition (EMT). Importantly, KiSS1 was identified as a downstream target gene of TC0101441 and was downregulated by TC0101441 in EOC cells. After TC0101441 was silenced, the corresponding phenotypes of EOC cell invasion and EMT were reversed by the overexpression of KiSS1. Taken together, our data suggest that TC0101441 functions as a potential promigratory\/invasive oncogene by promoting EMT and metastasis in EOC through downregulation of KiSS1, which may represent a novel prognostic marker and therapeutic target in EOC.<\/jats:p>","DOI":"10.1002\/ijc.32692","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T16:05:57Z","timestamp":1570032357000},"page":"2588-2598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Long noncoding RNA TC0101441 induces epithelial\u2013mesenchymal transition in epithelial ovarian cancer metastasis by downregulating KiSS1"],"prefix":"10.1002","volume":"146","author":[{"given":"Jun\u2010Jun","family":"Qiu","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital Fudan University  Shanghai China"},{"name":"Obstetrics and Gynecology Department of Shanghai Medical College Fudan University  Shanghai 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