{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:22:17Z","timestamp":1777288937708,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Previous studies on the risk of cancer after total hip arthroplasty (THA) contradict each other, and many are hampered by small cohort sizes, residual confounding, short observation times or a mix of indications underlying the THA procedure. We evaluated the risk of cancer after total hip arthroplasty due to osteoarthritis in a nationwide cohort by comparing cancer incidences in individuals exposed to total hip arthroplasty due to osteoarthritis and in unexposed, sex\u2010, age\u2010 and residence matched individuals. To address some previous studies\u2019 shortcomings, information on comorbidity and socioeconomic background were obtained and adjusted for. We included 126,276 patients exposed to a cemented THA between 1992 and 2012, and 555,757 unexposed individuals. Follow\u2010up started on the day of surgery for exposed individuals and respective date for matched, unexposed individuals, and ended on the day of death, emigration, censuring or December 31st, 2012, whichever came first. The Swedish Hip Arthroplasty Registry (SHAR), the Swedish Cancer Registry, the Swedish National Patient Registry and Statistics Sweden were accessed to obtain information on procedural details of the THA, cancer diagnoses, comorbidities, and socioeconomic background. The primary outcome measure was the occurrence of any cancer after the index date. Exposed individuals had a slightly lower adjusted risk of developing any cancer than unexposed individuals (hazard ratio [HR] 0.97; CI 0.95\u20130.99). The only cancer with a statistically significant risk increase in exposed individuals was skin melanoma (HR 1.15; CI 1.05\u20131.24). We attained similar risk estimates in analyses stratified by sex, in individuals with minimum 5\u2009years of follow\u2010up, in an analysis including individuals with a history of previous cancer, and in patients with cementless THA. In this study on a large and well\u2010defined population with long follow\u2010up, we found no increased overall risk of cancer after THA. These reassuring findings could be included in the guidelines on preoperative information given to THA patients.<\/jats:p>","DOI":"10.1002\/ijc.32711","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:20:06Z","timestamp":1570580406000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["No generally increased risk of cancer after total hip arthroplasty performed due to osteoarthritis"],"prefix":"10.1002","volume":"147","author":[{"given":"Nils P.","family":"Hailer","sequence":"first","affiliation":[{"name":"Section of Orthopaedics, Department of Surgical Sciences Uppsala University Hospital  Uppsala Sweden"},{"name":"Swedish Hip Arthroplasty Register  Goteborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-1516","authenticated-orcid":false,"given":"Anne","family":"Garland","sequence":"additional","affiliation":[{"name":"Section of Orthopaedics, Department of Surgical Sciences Uppsala University Hospital  Uppsala Sweden"},{"name":"Swedish Hip Arthroplasty Register  Goteborg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Gordon","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Clinical Sciences at Danderyd Hospital Division of Orthopaedics  Stockholm Sweden"},{"name":"Danderyd University Hospital Corporation, Department of Orthopaedics  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"K\u00e4rrholm","sequence":"additional","affiliation":[{"name":"Swedish Hip Arthroplasty Register  Goteborg Sweden"},{"name":"Department of Orthopaedics, Institute of Clinical Sciences The Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Sk\u00f6ldenberg","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Clinical Sciences at Danderyd Hospital Division of Orthopaedics  Stockholm Sweden"},{"name":"Danderyd University Hospital Corporation, Department of Orthopaedics  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niclas","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center Uppsala Science Park  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Garmo","sequence":"additional","affiliation":[{"name":"Section of Orthopaedics, Department of Surgical Sciences Uppsala University Hospital  Uppsala Sweden"},{"name":"King's College London, School of Cancer and Pharmaceutical Sciences Translational Oncology &amp; Urology Research (TOUR)  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Section of Orthopaedics, Department of Surgical Sciences Uppsala University Hospital  Uppsala Sweden"},{"name":"King's College London, School of Cancer and Pharmaceutical Sciences Translational Oncology &amp; Urology Research (TOUR)  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(96)80029-1"},{"key":"e_1_2_7_3_1","unstructured":"Swedish Hip Arthroplasty Register (SHAR).2017. 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