{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:12:21Z","timestamp":1789542741406,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>This study aimed to compare the differences in characteristics and prognoses between Asian and white patients receiving immunotherapy for nonsmall cell lung cancer (NSCLC). We studied 390 patients who received atezolizumab as part of the POPLAR or OAK trial, and analyzed the differences in baseline characteristics, outcomes and genetic mutations in blood samples between Asian and white patients. Overall survival (OS) was longer in Asian compared to white patients (median OS: 18.7 <jats:italic>vs<\/jats:italic>. 11.1\u2009months; <jats:italic>p<\/jats:italic> = 0.005). Race was identified as an independent prognostic factor for OS (Asian <jats:italic>vs<\/jats:italic>. white: hazard ratio 0.647, 95% confidence interval 0.447\u20130.936, <jats:italic>p<\/jats:italic> = 0.021), together with performance status, histology, baseline sum of the longest tumor diameters (BLSLD) and number of metastatic sites. The two groups also differed in terms of characteristics including smoking history, BLSLD, epidermal growth factor receptor (<jats:italic>EGFR<\/jats:italic>) mutation frequency, programmed death\u2010ligand 1 expression and blood\u2010based tumor\u2010mutation burden. Blood mutations of <jats:italic>STK11<\/jats:italic>, <jats:italic>EGFR<\/jats:italic>, <jats:italic>KEAP1<\/jats:italic>, <jats:italic>POLE<\/jats:italic>, <jats:italic>GRM3<\/jats:italic>, <jats:italic>ATM<\/jats:italic> and <jats:italic>STAG2<\/jats:italic> were associated with treatment response, and <jats:italic>TP53<\/jats:italic>, <jats:italic>KEAP1<\/jats:italic>, <jats:italic>APC<\/jats:italic>, <jats:italic>RB1<\/jats:italic>, <jats:italic>CREBBP<\/jats:italic>, <jats:italic>EPHA5<\/jats:italic> and <jats:italic>STAG2<\/jats:italic> mutations were associated with OS. The blood\u2010based mutation profiles differentiated between Asian and white patients, especially in relation to <jats:italic>EGFR<\/jats:italic> (23.8 <jats:italic>vs<\/jats:italic>. 8.5%), <jats:italic>TP53<\/jats:italic> (30.2 <jats:italic>vs<\/jats:italic>. 46.9%) and <jats:italic>STK11<\/jats:italic> (1.6 <jats:italic>vs<\/jats:italic>. 12.3%) mutations (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The different clinicopathological features and mutation profiles in Asian and white patients may explain the superior outcome following atezolizumab treatment in Asian patients with NSCLC. The results of this study have important implications for further studies on racial disparities in relation to immunotherapy.<\/jats:p>","DOI":"10.1002\/ijc.32717","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T03:00:45Z","timestamp":1570158045000},"page":"3124-3133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Racial differences in characteristics and prognoses between Asian and white patients with nonsmall cell lung cancer receiving atezolizumab: An ancillary analysis of the POPLAR and OAK studies"],"prefix":"10.1002","volume":"146","author":[{"given":"Jie","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Emergency Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University  Shanghai 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