{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:31:05Z","timestamp":1791919865468,"version":"4.3.4"},"reference-count":198,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,5,15]]},"abstract":"<jats:p>HIV infected people are at higher risk of developing cancer, although it is globally diminished in the era of highly active antiretroviral treatment (HAART). Recently, antioncogenic properties of some HAART drugs were discovered. We discuss the role of HAART in the prevention and improvement of treatment outcomes of cancers in HIV\u2010infected people. We describe different trends in HAART\u2013cancer relationships: cancer\u2010predisposing as well as cancer\u2010preventing. We cover the roles of particular drug regimens in cancer prevention. We also describe the causes of cancer treatment with HAART drugs in HIV\u2010negative people, including ongoing clinical studies that may directly point to a possible independent anti\u2010oncogenic activity of HAART drugs. We conclude that despite potent antioncogenic activities of every class of HAART drugs reported in preclinical models, the evidence to date indicates that their independent clinical impact in HIV\u2010infected people is limited. Improved cancer prevention strategies besides HAART are needed to reduce HIV\u2010cancer\u2010related mortality.<\/jats:p>","DOI":"10.1002\/ijc.32730","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T16:58:38Z","timestamp":1570813118000},"page":"2666-2679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["HIV\u20101, HAART and cancer: A complex relationship"],"prefix":"10.1002","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-074X","authenticated-orcid":false,"given":"Anna","family":"Shmakova","sequence":"first","affiliation":[{"name":"UMR 8126, CNRS, Univ. Paris\u2010Sud Institut Gustave Roussy Universit\u00e9 Paris Saclay  \u00c9douard\u2010Vaillant Villejuif France"},{"name":"LIA 1066 LFR2O French\u2010Russian Joint Cancer Research Laboratory  \u00c9douard\u2010Vaillant Villejuif France"},{"name":"Laboratory of Gene and Cell Technologies, Faculty of Medicine Lomonosov Moscow State University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Germini","sequence":"additional","affiliation":[{"name":"UMR 8126, CNRS, Univ. Paris\u2010Sud Institut Gustave Roussy Universit\u00e9 Paris Saclay  \u00c9douard\u2010Vaillant Villejuif France"},{"name":"LIA 1066 LFR2O French\u2010Russian Joint Cancer Research Laboratory  \u00c9douard\u2010Vaillant Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-7043","authenticated-orcid":false,"given":"Yegor","family":"Vassetzky","sequence":"additional","affiliation":[{"name":"UMR 8126, CNRS, Univ. Paris\u2010Sud Institut Gustave Roussy Universit\u00e9 Paris Saclay  \u00c9douard\u2010Vaillant Villejuif France"},{"name":"LIA 1066 LFR2O French\u2010Russian Joint Cancer Research Laboratory  \u00c9douard\u2010Vaillant Villejuif France"},{"name":"Koltzov Institute of Developmental Biology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283324283"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.6626"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.5967"},{"key":"e_1_2_12_5_1","unstructured":"EngelsEA YanikEL WheelerW et al.Cancer\u2010attributable mortality among people with treated human immunodeficiency virus infection in North America.2017;65:636\u201343."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2016.0222"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328317cc2d"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605756"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001112"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30125-X"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir626"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju503"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001554"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000922"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1252332"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604520"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f2705d"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji072"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000327"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70282-7"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001394"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-275917"},{"key":"e_1_2_12_23_1","first-page":"83","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview","volume":"102","author":"Sabattini E","year":"2010","journal-title":"Pathologica"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000428"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0273"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.12.012"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt158"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2499"},{"issue":"8","key":"e_1_2_12_29_1","first-page":"124","article-title":"Characteristics of AIDS\u2010related and non\u2010AIDS\u2010related cancers in an Italian cohort of HIV patients in the period 1996\u20132018","volume":"21","author":"Nicol\u00e8 S","year":"2018","journal-title":"J Int AIDS Soc"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2014.08.003"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq447"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0777"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f7cb76"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283112b77"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir207"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181b033ab"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.4413"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181f53783"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0066"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy010"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-10-200805200-00005"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2652-14-16"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000202"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.02.022"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.8.4846"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511786200"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.77"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00150"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016208783571991"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.4.1.1377"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.4255\/mcpharmacol.09.10"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0643"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-1079"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0964"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001033"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8644"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29603"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186549"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.9613"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1310\/VQXJ-41X6-GJA2-H6AG"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200111090-00007"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22275"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-7-S1-O18"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010101)91:1<155::AID-CNCR20>3.0.CO;2-B"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603056"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2572"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.3843.3843"},{"key":"e_1_2_12_68_1","first-page":"44","article-title":"Acquired immunodeficiency syndrome\u2010related Kaposi's sarcoma regression after highly active antiretroviral therapy: biologic correlates of clinical outcome","volume":"28","author":"Cattelan AM","year":"2001","journal-title":"J Natl Cancer Inst Monogr"},{"key":"e_1_2_12_69_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5070\/D34354D2QV","article-title":"Letter: Penile Kaposi sarcoma: a case of complete resolution with highly active antiretroviral therapy alone","volume":"17","author":"Pinto\u2010Almeida T","year":"2011","journal-title":"Dermatol Online J"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008016"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.116186"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325957414521868"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416686512"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.9642"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009050"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199812000-00007"},{"key":"e_1_2_12_77_1","doi-asserted-by":"crossref","unstructured":"BlitzS BaxterJ RaboudJ et al.Canadian Women's HIV Study group. Evaluation of HIV and highly active antiretroviral therapy on the natural history of human papillomavirus infection and cervical cytopathologic findings in HIV\u2010positive and high\u2010risk HIV\u2010negative women.2013;208.","DOI":"10.1093\/infdis\/jit181"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318251aedd"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0620-1"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.973"},{"key":"e_1_2_12_81_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1177\/135965350701200609","article-title":"Swiss HIV cohort Study. Treatment and prognosis of AIDS\u2010related lymphoma in the era of highly active antiretroviral therapy: findings from the Swiss HIV cohort Study","volume":"12","author":"Simcock M","year":"2007","journal-title":"Antivir Ther"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000986"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.2810"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyi093"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10113"},{"key":"e_1_2_12_86_1","first-page":"1937","article-title":"Regression of a cervical spinal mass following highly active antiretroviral therapy (HAART) in child with advanced human immunodeficiency virus (HIV) disease","volume":"90","author":"Leng LK","year":"2007","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200303000-00001"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.11.018"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28554"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00071"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12589"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.10.013"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32832f3e04"},{"key":"e_1_2_12_94_1","first-page":"e492","article-title":"Selected pharmacogenetic panel test for toxicity prevention of drug\u2010drug interactions between highly active antiretroviral therapy (HAART) and antiblastic","volume":"2","author":"Di Francia R","year":"2015","journal-title":"World Cancer Res J"},{"key":"e_1_2_12_95_1","volume-title":"Guidelines for the use of antiretroviral agents in adults and adolescents with HIV","author":"Department of Health and Human Services","year":"2019"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181aa13c7"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001053"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000523"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28894"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20309"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835935b3"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq134"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21334"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204172"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-301531"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-339275"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12429"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000645"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1086\/518606"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e31825aa764"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000537"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328331f6e2"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4201-6"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27694"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.20195"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328311d18b"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000194735.66322.d9"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001051"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.22162"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200307250-00001"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11648"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.03.002"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200212010-00003"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200307040-00028"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31816d9d2b"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200405210-00024"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001588"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.11.037"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12557"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1086\/518797"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2012.05.008"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182a7a97a"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328032"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142966"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-017-0434-1"},{"issue":"8","key":"e_1_2_12_136_1","first-page":"121","article-title":"Anal cancer risk and use of a protease inhibitor: a nested case\u2010control study within the ANRS CO4\u2010FHDH cohort","volume":"21","author":"Grabar S","year":"2018","journal-title":"J Int AIDS Soc"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0161"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1167"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs396"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155970"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.5827.2"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30529"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e328313915d"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.180201"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160921138"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24947"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2014.912836"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.12.004"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19048"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/890141"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161213804143725"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17007"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmhg.2017.07.004"},{"key":"e_1_2_12_154_1","first-page":"6055","article-title":"Could the FDA\u2010approved anti\u2010HIV PR inhibitors be promising anticancer agents? An answer from enhanced docking approach and molecular dynamics analyses","volume":"9","author":"Arodola O","year":"2015","journal-title":"Drug Des Dev Ther"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.07.032"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01295-10"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01229-10"},{"key":"e_1_2_12_158_1","first-page":"1617","article-title":"Different cell cycle modulation in SKOV\u20103 ovarian Cancer cell line by anti\u2010HIV drugs","volume":"25","author":"Perna A","year":"2017","journal-title":"Oncol Res Featur Preclin Clin Cancer Ther"},{"key":"e_1_2_12_159_1","doi-asserted-by":"crossref","unstructured":"CarliniF RidolfiB MolinariA et al.The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines.2010;5:e14221.","DOI":"10.1371\/journal.pone.0014221"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780249191"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-011-9704-7"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16097994"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2017.00074"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.119"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206354"},{"key":"e_1_2_12_166_1","first-page":"1728","article-title":"Cytotoxic effect of Efavirenz in BxPC\u20103 pancreatic cancer cells is based on oxidative stress and is synergistic with ionizing radiation","volume":"15","author":"Hecht M","year":"2017","journal-title":"Oncol Lett"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20923"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130277"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5243"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208562"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.07.002"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305066110"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-016-0305-6"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0313"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-018-0415-3"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.196725"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3917"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10227"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0612"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.005"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283262a8d"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.2355"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182435aa6"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.03.023"},{"key":"e_1_2_12_185_1","doi-asserted-by":"crossref","unstructured":"DriessenC MullerR NovakU et al. The HIV protease inhibitor nelfinavir in combination with bortezomib and dexamethasone (NVd) has excellent activity in patients with advanced proteasome inhibitor\u2010refractory multiple myeloma: a multicenter phase II trial (SAKK 39\/13). 58th Annual Meeting of the American Society of Hematology ASH 2016. December 3\u20136 2016; 128","DOI":"10.1182\/blood.V128.22.487.487"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2415"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1303-3"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.03.021"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147917"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2006.316"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70908-1"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23664"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0345"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0325-3"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545109709341852"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23487"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328331d384"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000520"},{"key":"e_1_2_12_199_1","volume-title":"EACS guidelines 9.1","author":"European AIDS Clinical Society","year":"2018"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.32730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.32730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.32730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T15:02:59Z","timestamp":1694098979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.32730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":198,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,5,15]]}},"alternative-id":["10.1002\/ijc.32730"],"URL":"https:\/\/doi.org\/10.1002\/ijc.32730","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"2019-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}