{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:59:42Z","timestamp":1792421982132,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>For patients ineligible for cisplatin with definitive radiotherapy (CP\u2010CRT) for locally advanced head and neck squamous cell carcinoma (LA\u2010HNSCC), concurrent cetuximab (C225\u2010RT) is a popular substitute. Carboplatin\u2010based chemoradiation (CB\u2010CRT) is another option; however, relative efficacies of CP\u2010CRT, CB\u2010CRT and C225\u2010RT are unclear, particularly in the human papillomavirus (HPV)\u2010unrelated population. We identified 316 patients with stage III\u2010IVB cancers of the oropharynx (24.7%), larynx (58.2%) and hypopharynx (17.1%) undergoing definitive C225\u2010RT (<jats:italic>N<\/jats:italic> = 61), CB\u2010CRT (<jats:italic>N<\/jats:italic> = 74) or CP\u2010CRT (<jats:italic>N<\/jats:italic> = 181). Kaplan\u2010Meier and cumulative incidence functions were generated to estimate overall survival (OS), locoregional failure (LRF) and distant metastasis (DM). Cox proportional hazards were used to determine the association of survival endpoints with clinical characteristics. Respectively, 3\u2010year cumulative incidences for CP\u2010CRT, CB\u2010CRT and C225\u2010RT were: LRF (0.19, 0.18 and 0.48, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001), DM (0.17, 0.12 and 0.25, <jats:italic>p<\/jats:italic> = 0.32). Kaplan\u2010Meier estimates for 3 year OS were: CP\u2010CRT: 71%; CB\u2010CRT: 59% and C225\u2010RT: 54%; <jats:italic>p<\/jats:italic> = 0.0094. CP\u2010CRT (hazard ratio [HR] 0.336; 95% confidence interval [CI] 0.203\u20130.557, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and CB\u2010CRT (HR 0.279; 95% CI 0.141\u20130.551, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were associated with reduced hazard for LRF on multivariable analysis. CP\u2010CRT (HR 0.548; 95% CI 0.355\u20130.845, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and CB\u2010CRT (HR 0.549; 95% CI 0.334\u20130.904, <jats:italic>p<\/jats:italic> = 0.02) were associated with a reduced hazard for death on multivariable analysis. Propensity matching confirmed reduced hazards with a combined CP\/CB\u2010CRT group compared to C225\u2010RT for LRF: HR 0.384 (<jats:italic>p<\/jats:italic> = 0.018) and OS: HR 0.557 (<jats:italic>p<\/jats:italic> = 0.045) and CB\u2010CRT group compared to C225\u2010RT for LRF: HR 0.427 (<jats:italic>p<\/jats:italic> = 0.023). In conclusion, CB\u2010CRT is an effective alternative to CP\u2010CRT in HPV\u2010unrelated LA\u2010HNSCC with superior locoregional control and OS compared to C225\u2010RT.<\/jats:p>","DOI":"10.1002\/ijc.32736","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T15:49:53Z","timestamp":1571068193000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Platinum\u2010based regimens <i>versus<\/i> cetuximab in definitive chemoradiation for human papillomavirus\u2010unrelated head and neck cancer"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-6996","authenticated-orcid":false,"given":"Thomas H.","family":"Beckham","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Barney","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Wexner Medical Center  Columbus OH"},{"name":"Methodist Health System  Omaha NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Healy","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Wexner Medical Center  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Wexner Medical Center  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Branstetter","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Wexner Medical Center  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Yaney","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The Ohio State University Wexner Medical Center  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Riaz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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