{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:39:39Z","timestamp":1793648379772,"version":"4.5.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K01CA21845701A1"],"award-info":[{"award-number":["K01CA21845701A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1 CA173642"],"award-info":[{"award-number":["UM1 CA173642"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:p>In the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) cohort, we examined predictors of guideline\u2010concordant treatment among endometrial cancer (EC) survivors and associations between receipt of guideline\u2010concordant treatment and survival. Receipt of guideline\u2010concordant EC treatment was defined according to year\u2010specific National Comprehensive Cancer Network (NCCN) guidelines. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for predictors of guideline\u2010concordant treatment receipt. We estimated multivariable\u2010adjusted hazard ratios (HRs) and 95% CIs for relationships between guideline\u2010concordant treatment and overall survival using Cox proportional hazards regression. We included 629 women with EC, of whom 83.6% (<jats:italic>n<\/jats:italic> =\u2009526) received guideline\u2010concordant treatment. Receipt of guideline\u2010concordant treatment was less common among women with nonendometrioid histology (OR = 0.24, 95% CI = 0.13\u20130.45) but was more common among women living in the Midwest (OR = 2.09, 95% CI = 1.06\u20134.12) or West (OR = 3.02, 95% CI = 1.49\u20136.13) compared to the Northeast. In Cox regression models adjusted for age, histology and stage, receipt of guideline\u2010concordant EC treatment was borderline associated with improved overall survival (HR = 0.80, 95% CI = 0.60\u20131.01) in the overall population. Guideline\u2010concordant treatment was also linked with better overall survival among women with low\u2010grade uterine\u2010confined endometrioid EC or widely metastatic endometrioid EC. Guideline\u2010concordant treatment varies by some patient characteristics and those women in receipt of guideline\u2010concordant care had borderline improved survival. Studies evaluating regional differences in treatment along with randomized clinical trials to determine appropriate treatment regimens for women with aggressive tumor characteristics are warranted.<\/jats:p>","DOI":"10.1002\/ijc.32740","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T22:30:42Z","timestamp":1571265042000},"page":"404-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Guideline\u2010concordant endometrial cancer treatment and survival in the Women's Health Initiative Life and Longevity After Cancer study"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8347-9018","authenticated-orcid":false,"given":"Ashley S.","family":"Felix","sequence":"first","affiliation":[{"name":"Division of Epidemiology College of Public Health, The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bette J.","family":"Caan","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente  Oakland CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Cohn","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology College of Medicine, The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garnet L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center  Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Electra D.","family":"Paskett","sequence":"additional","affiliation":[{"name":"Division of Epidemiology College of Public Health, The Ohio State University  Columbus OH"},{"name":"Division of Cancer Prevention and Control College of Medicine, The Ohio State University  Columbus OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60031-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.048"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.06.036"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0735"},{"key":"e_1_2_8_8_1","unstructured":"National Comprehensive Cancer Network. 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