{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:12:09Z","timestamp":1776409929475,"version":"3.51.2"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007903","name":"Bloodwise","doi-asserted-by":"publisher","award":["15037"],"award-info":[{"award-number":["15037"]}],"id":[{"id":"10.13039\/501100007903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["18362"],"award-info":[{"award-number":["18362"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Associations between previous joint replacement and B\u2010cell lymphoid malignancies have been reported, but despite numerous reports, associations with the disease subtypes have received little attention. Using a UK\u2010based register of haematological malignancies and a matched general population\u2010based cohort, joint replacements from linked hospital inpatient records were examined. Cases diagnosed 2009\u20132015 who were aged 50\u2009years or more were included; 8,013 mature B\u2010cell neoplasms comprising myeloma (<jats:italic>n<\/jats:italic> =\u20091,763), diffuse large B\u2010cell lymphoma (DLBCL, <jats:italic>n<\/jats:italic> =\u20091,676), chronic lymphocytic leukaemia (CLL, <jats:italic>n<\/jats:italic> =\u20091,594), marginal zone lymphoma (MZL, <jats:italic>n<\/jats:italic> =\u2009957), follicular lymphoma (FL, <jats:italic>n<\/jats:italic> =\u2009725) and classical Hodgkin lymphoma (CHL, <jats:italic>n<\/jats:italic> =\u2009255), together with monoclonal gammopathy of uncertain significance (MGUS, <jats:italic>n<\/jats:italic> =\u20092,138) and monoclonal B\u2010cell lymphocytosis (MBL, <jats:italic>n<\/jats:italic> =\u2009632). Odds ratios (OR) and 95% confidence intervals (95%CI) were calculated relative to 10 age\u2010 and sex\u2010matched controls using conditional logistic regression. Having had a joint replacement before diagnosis was associated with myeloma (OR\u2009=\u20091.3, 95% CI 1.1\u20131.5, <jats:italic>p<\/jats:italic> =\u20090.008) and MGUS (OR\u2009=\u20091.3, 95% CI 1.1\u20131.5, <jats:italic>p<\/jats:italic> &lt;\u20090.001). Excluding replacements in the year before diagnosis, the MGUS risk remained, elevated where two or more joints were replaced (OR\u2009=\u20091.5, 95% CI 1.2\u20132.0, <jats:italic>p<\/jats:italic> =\u20090.001), with hip (OR\u2009=\u20091.2, 95% CI 1.0\u20131.5, <jats:italic>p<\/jats:italic> =\u20090.06) or knee replacements (OR\u2009=\u20091.5, 95% CI 1.2\u20131.8, <jats:italic>p<\/jats:italic> &lt;\u20090.001). Associations with CHL and two or more replacements (OR\u2009=\u20092.7, 95% CI 1.3\u20135.6, <jats:italic>p<\/jats:italic> =\u20090.005) or hip replacements (OR\u2009=\u20091.9, 95% CI 1.0\u20133.4, <jats:italic>p<\/jats:italic> =\u20090.04); and between DLBCL and knee replacements (OR\u2009=\u20091.3, 95% CI 1.0\u20131.6, <jats:italic>p<\/jats:italic> =\u20090.04) were also observed. Our study reports for the first time a relationship between joint replacements and MGUS; while absolute risks of disease are low and not of major public health concern, these findings warrant further investigation.<\/jats:p>","DOI":"10.1002\/ijc.32765","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T15:48:39Z","timestamp":1572623319000},"page":"702-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk of mature B\u2010cell neoplasms and precursor conditions after joint replacement: A report from the Haematological Malignancy Research Network"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7438-9982","authenticated-orcid":false,"given":"Eleanor","family":"Kane","sequence":"first","affiliation":[{"name":"Epidemiology and Cancer Statistics Group, Department of Health Sciences University of York  York United 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