{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:23:26Z","timestamp":1770895406403,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T00:00:00Z","timestamp":1577491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Women with cervical intraepithelial neoplasia grade 3 (CIN3) have a long\u2010lasting increased risk for noncervical high\u2010risk human papillomavirus (hrHPV)\u2010related (pre)malignancies. The aim of our study was to estimate this risk in women with recurrent CIN3 compared to women without a history of CIN3 and women with a single episode of CIN3. Women with a CIN3 diagnosis between 1990 and 2010 were obtained from the Dutch Pathology Registry (PALGA) and matched with a control group of women without CIN3. Analysis has been conducted in a subset of women with recurrent CIN3, defined as reoccurrence minimally 2\u2009years post\u2010treatment. Cases of noncervical hrHPV\u2010related (pre)malignancies of the anus, vulva, vagina and oropharynx were identified until 2015 and incidence rate ratios (IRRs) were estimated. Then, 1,797 women with recurrent CIN3 were included with a median age of 34\u2009years (range 18\u201376) and 31,594 person\u2010years of follow\u2010up. Women with recurrent CIN3 had an increased risk of developing noncervical hrHPV\u2010related (pre)malignancies compared to women without CIN3 with an IRR of 25.96 (95%CI 6.32\u2013106.58). The IRR was 2.48 (95% CI 1.87\u20133.30) compared to women with a single episode of CIN3. Studies on posttreatment follow\u2010up and prophylactic hrHPV vaccination are warranted.<\/jats:p>","DOI":"10.1002\/ijc.32834","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T15:43:44Z","timestamp":1576597424000},"page":"897-900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The relative risk of noncervical high\u2010risk human papillomavirus\u2010related (pre)malignancies after recurrent cervical intraepithelial neoplasia grade 3: A population\u2010based study"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-8112","authenticated-orcid":false,"given":"Diede L.","family":"Loopik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Radboud Institute for Molecular Life Sciences, Radboud university medical center  Nijmegen The 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Gynaecology Radboud university medical center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruud L.","family":"Bekkers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert G.","family":"Siebers","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud university medical center  Nijmegen The Netherlands"},{"name":"PALGA, The Nationwide Network and Registry of Histo\u2010 and Cytopathology  Houten The 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