{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:44:25Z","timestamp":1770957865514,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>To identify the risk factors of oral cancer, we investigated the association between chronic hepatitis C (CHC) and oral cancer, and the development of oral cancer after anti\u2010hepatitis C virus (HCV) therapy. We conducted a nationwide, population\u2010based cohort study from 2004 to 2012 from the Taiwan National Health Insurance Research Database. CHC patients without anti\u2010HCV therapy were matched with those non\u2010HCV patients by age, sex and comorbidities. Moreover, CHC patients who underwent pegylated interferon and ribavirin (PegIFN\/RBV) anti\u2010HCV therapy were matched with CHC patients without anti\u2010HCV therapy. A total of 100,058 patients were included in the HCV cohort and non\u2010HCV cohorts, respectively. Their mean age was 59\u2009years and 50% of these were male. CHC infection significantly increased the cumulative incidence of lichen planus and oral cancer. After adjustment for confounders and competing mortality, CHC infection significantly increased the risk of oral cancer (hazard ratio [HR]: 1.677, 95% confidence interval [CI]: 1.392\u20132.020, <jats:italic>p<\/jats:italic> &lt;\u20090.001). Another 23,735 CHC patients without anti\u2010HCV therapy were matched with 23,735 CHC patients in the treatment cohort. After adjustment for confounders and competing for mortality, the risk of oral cancer was significantly reduced in CHC patients receiving anti\u2010HCV therapy (HR: 0.652, 95% CI: 0.479\u20130.887, <jats:italic>p<\/jats:italic> =\u20090.007). To minimize the inclusion of pre\u2010existing unidentified oral cancer, we excluded oral cancer developed within the first year of CHC or anti\u2010HCV therapy and found these associations remained statistically significant. In conclusion, CHC significantly increases the risk of oral cancer. Moreover, PegIFN\/RBV antiviral therapy significantly reduces the risk of HCV\u2010related oral cancer.<\/jats:p>","DOI":"10.1002\/ijc.32840","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T09:10:13Z","timestamp":1576746613000},"page":"901-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antiviral therapy against chronic hepatitis C is associated with a reduced risk of oral cancer"],"prefix":"10.1002","volume":"147","author":[{"given":"Tung\u2010Hung","family":"Su","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei 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