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In total, 347 patients were analysed; the median age was 63\u2009years (range 23\u201390). The primary tumour was in the duodenum (60.6%), jejunum (20.7%) and ileum (18.7%). The prevalence of predisposing disease was 8.7%, 6.9%, 1.7%, 1.7% and 0.6% for Crohn disease, Lynch syndrome, familial adenomatous polyposis, celiac disease and Peutz\u2010Jeghers syndrome, respectively. At diagnosis, 58.9%, 5.5% and 35.6% of patients had localised and resectable, locally advanced unresectable and metastatic disease, respectively. Crohn disease was significantly associated with younger age, poor differentiation and ileum location, whereas Lynch syndrome with younger age, poor differentiation, early stage and duodenum location. Adjuvant chemotherapy (oxaliplatin\u2010based in 89.9%) was performed in 61.5% of patients with locally resected tumours. With a 54\u2010months median follow\u2010up, the 5\u2010year overall survival (OS) was 87.9%, 78.2% and 55.5% in Stages I, II and III, respectively. The median OS of patients with Stage IV was 12.7 months. In patients with resected tumours, poor differentiation (<jats:italic>p<\/jats:italic> = 0.047) and T4 stage (<jats:italic>p<\/jats:italic> = 0.001) were associated with a higher risk of death. In conclusion, our study showed that the prognosis of advanced SBA remains poor. Tumour characteristics differed according to predisposing disease. In SBA\u2010resected tumours, the prognostic factors for OS were grade and T stage.<\/jats:p>","DOI":"10.1002\/ijc.32860","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T02:20:42Z","timestamp":1578450042000},"page":"967-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Small bowel adenocarcinoma: Results from a nationwide prospective ARCAD\u2010NADEGE cohort study of 347 patients"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-6927","authenticated-orcid":false,"given":"Thomas","family":"Aparicio","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Digestive Oncology Saint Louis Hospital, APHP, University Paris Diderot  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Henriques","sequence":"additional","affiliation":[{"name":"Methodology and Quality of Life 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