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Emerging data support the model that fallopian tubes are the site of origin for a proportion of high\u2010grade serous cancers. This implies that a subset of cancers may be prevented by removing the fallopian tubes while leaving the ovaries intact. Accordingly, there has been shift in clinical practice for average risk women; some now recommend removal of both the fallopian tubes only instead of tubal ligation for sterilization or at the time of benign gynecologic surgery. This has been termed\n                    <jats:italic>opportunistic salpingectomy<\/jats:italic>\n                    and represents a means of decreasing the burden of ovarian cancer by preventing cancers that arise in the fallopian tubes. There have been no detailed, prospective reports that have estimated ovarian cancer risk reduction with opportunistic salpingectomy, neither among women at baseline population risk nor among women at a high risk of developing the disease. The situation is complicated for women with a\n                    <jats:italic>BRCA<\/jats:italic>\n                    mutation\u2014bilateral salpingo\u2010oophorectomy is a proven means of risk reduction and salpingectomy alone is not the standard of care. Based on the existing data, salpingectomy alone should only be reserved for women with a lifetime risk of ovarian cancer of less than 5%.\n                  <\/jats:p>","DOI":"10.1002\/ijc.32916","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T02:04:50Z","timestamp":1581300290000},"page":"1245-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prophylactic salpingectomy for the prevention of ovarian cancer: Who should we target?"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-4218","authenticated-orcid":false,"given":"Joanne","family":"Kotsopoulos","sequence":"first","affiliation":[{"name":"Women's College Research Institute Women's College Hospital  Toronto Ontario Canada"},{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario 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