{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:06:29Z","timestamp":1793833589730,"version":"4.6.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372832"],"award-info":[{"award-number":["81372832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772824"],"award-info":[{"award-number":["81772824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974422"],"award-info":[{"award-number":["81974422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,6,15]]},"abstract":"<jats:p>To estimate the cumulative risk of contralateral breast cancer (CBC) in <jats:italic>BRCA1\/2<\/jats:italic> carriers in a large cohort of unselected Chinese breast cancer patients. Our study comprised 9,401 unselected Chinese breast cancer patients and <jats:italic>BRCA1\/2<\/jats:italic> germline mutations were determined in all patients. After a median follow\u2010up of 5.7\u2009years, 181 patients developed CBC in this cohort. Compared to noncarriers, <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> carriers had a 4.52\u2010fold (95% CI, 2.63\u20137.76) and 5.54\u2010fold (95% CI, 3.51\u20138.74) increased risk of CBC, respectively. The 10\u2010year cumulative risk of CBC was 15.5% (95% CI, 9.9\u201324.2) for <jats:italic>BRCA1<\/jats:italic> carriers, 17.5% (95% CI, 10.9\u201328.0) for <jats:italic>BRCA2<\/jats:italic> carriers and 3.2% (95% CI, 2.5\u20134.1) for noncarriers. Younger age at first breast cancer diagnosis was significantly associated with an increased 10\u2010year risk of CBC for <jats:italic>BRCA1<\/jats:italic> carriers (\u226440\u2009years <jats:italic>vs<\/jats:italic>. &gt;40\u2009years: 21.5% <jats:italic>vs<\/jats:italic>. 11.9%, unadjusted hazard ratio [HR] = 2.51, 95% CI, 1.03\u20136.15, <jats:italic>p<\/jats:italic> = 0.044), but not for <jats:italic>BRCA2<\/jats:italic> carriers and noncarriers. The 10\u2010year cumulative CBC risk was significantly higher in both <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> carriers who had a family history of breast cancer than in those who did not (<jats:italic>BRCA1<\/jats:italic>: 27.5% <jats:italic>vs<\/jats:italic>. 9.4%, adjusted HR = 2.64, 95% CI, 1.01\u20136.97, <jats:italic>p<\/jats:italic> = 0.049; <jats:italic>BRCA2<\/jats:italic>: 27.1% <jats:italic>vs<\/jats:italic>. 12.8%, adjusted HR = 2.29, 95% CI, 1.04\u20135.06, <jats:italic>p<\/jats:italic> = 0.040). In conclusion, the risk of CBC was a substantial high in <jats:italic>BRCA1\/2<\/jats:italic> carriers in unselected Chinese breast cancer patients, and CBC risk is much more remarkable in both <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> carriers who had a family history of breast cancer. Younger age at first breast cancer diagnosis also enhanced CBC risk in <jats:italic>BRCA1<\/jats:italic> carriers.<\/jats:p>","DOI":"10.1002\/ijc.32918","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T07:25:05Z","timestamp":1581319505000},"page":"3335-3342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Contralateral breast cancer risk in <i>BRCA1<\/i> and <i>BRCA2<\/i> mutation carriers in a large cohort of unselected Chinese breast cancer patients"],"prefix":"10.1002","volume":"146","author":[{"given":"Liming","family":"Su","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center Beijing Cancer Hospital &amp; Institute, Peking University Cancer Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center Beijing Cancer Hospital &amp; Institute, Peking University Cancer Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center Beijing Cancer Hospital &amp; Institute, Peking University Cancer Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center Beijing Cancer Hospital &amp; Institute, Peking University Cancer Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center Beijing Cancer Hospital &amp; Institute, Peking University Cancer Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqing","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center Beijing Cancer Hospital &amp; Institute, Peking University Cancer Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center Beijing Cancer Hospital 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