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The influence of early life adiposity on risk of these precursors remains unclear. Within the Nurses' Health Study, the Nurses' Health Study 2, and the Health Professionals Follow\u2010up Study, we assessed body fatness during childhood using 9\u2010level somatotype and obtained weight and body mass index (BMI) in adulthood. We used multivariable\u2010adjusted logistic regression to examine the association of SPs and conventional adenomas with body fatness in early childhood (age 5), late childhood (age 10), early adulthood (age 18\/21) and middle adulthood (baseline) and weight change during early\u2010to\u2010middle adulthood. During 18\u201320\u2009years of follow\u2010up, we documented 8,697 SPs and 10,219 conventional adenomas in 132,514 women; 2,403 SPs and 4,495 conventional adenomas in 29,207 men. 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Our findings indicated a potential role in development of colorectal cancer precursors of childhood body fatness in women, and early\u2010to\u2010middle adulthood weight gain and attained adiposity in both sexes.<\/jats:p>","DOI":"10.1002\/ijc.32958","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T15:24:51Z","timestamp":1583767491000},"page":"1831-1844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Body fatness over the life course and risk of serrated polyps and conventional adenomas"],"prefix":"10.1002","volume":"147","author":[{"given":"Chun\u2010Han","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T.H. 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