{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:47:25Z","timestamp":1775983645568,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011272","name":"FP7 Health","doi-asserted-by":"publisher","award":["257144 ARTFORCE"],"award-info":[{"award-number":["257144 ARTFORCE"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["KWF\u2010AC6C7072"],"award-info":[{"award-number":["KWF\u2010AC6C7072"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,9,15]]},"abstract":"<jats:p>DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) is also characterized by high CNAs. In this study, we determined CNA in 173 human papilloma virus\u2010negative HNSCC from a Dutch multicenter cohort by low\u2010coverage whole genome sequencing and tested the prognostic value of seven cancer\u2010derived CNA signatures for these cisplatin\u2010 and radiotherapy\u2010treated patients. We find that a high CNA signature 1 (s1) score is associated with low values for all other signatures and better patient outcomes in the Dutch cohorts and The Cancer Genome Atlas HNSCC data set. High s5 and s7 scores are associated with increased distant metastasis rates and high s6 scores with poor overall survival. High cumulative cisplatin doses result in improved outcomes in chemoradiotherapy\u2010treated HNSCC patients. Here we find that tumors high in s1 or low in s6 are most responsive to a change in cisplatin dose. High s5 values, however, significantly increase the risk for metastasis in patients with low cumulative cisplatin doses. Together this suggests that the processes causing these CNA signatures affect cisplatin response in HNSCC. In conclusion, CNA signatures derived from a different cancer type were prognostic and associated with cisplatin response in HNSCC, suggesting they represent underlying molecular processes that define patient outcome.<\/jats:p>","DOI":"10.1002\/ijc.32962","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T12:19:20Z","timestamp":1584101960000},"page":"1732-1739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ovarian cancer\u2010derived copy number alterations signatures are prognostic in chemoradiotherapy\u2010treated head and neck squamous cell carcinoma"],"prefix":"10.1002","volume":"147","author":[{"given":"Paul B.M.","family":"Essers","sequence":"first","affiliation":[{"name":"Division of Cell Biology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Division of Cell Biology The Netherlands Cancer Institute  Amsterdam The Netherlands"},{"name":"Department of Head and Neck Oncology and Surgery The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Vossen","sequence":"additional","affiliation":[{"name":"Division of Cell Biology The Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinout H.","family":"de Roest","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Vrije Universiteit Amsterdam, Otolaryngology\/Head and Neck Surgery, Cancer Center Amsterdam  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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