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More effective, better tolerated treatments are therefore required to achieve durable remissions and to improve the quality of life of MM patients. Adoptive immunotherapy employing T cells expressing chimeric antigen receptors (CAR) is currently among the most promising treatment approaches in cancer. Within the target portfolio for MM immunotherapy, B\u2010cell maturation antigen (BCMA) is among the most widely studied target antigens. BCMA is consistently expressed on MM cells and, importantly, is not expressed in critical healthy tissue. For this reason, it is an ideal target for MM immunotherapy. Several clinical trials evaluating different BCMA\u2010targeting CAR constructs have been initiated and early results are very promising. However, in this rapidly developing clinical landscape, the ultimate role of BCMA\u2010specific CAR\u2010T cell therapy remains unclear. In this review, we will summarize currently available clinical data on BCMA\u2010directed CAR\u2010T cells and discuss potential future perspective for this promising treatment approach in MM.<\/jats:p>","DOI":"10.1002\/ijc.33002","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T08:36:02Z","timestamp":1586421362000},"page":"2029-2041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["B\u2010cell maturation antigen\u2010specific chimeric antigen receptor T cells for multiple myeloma: Clinical experience and future perspectives"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-401X","authenticated-orcid":false,"given":"Leopold","family":"Sellner","sequence":"first","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"},{"name":"National Center for Tumor Diseases (NCT) German Cancer 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