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These are termed remnant ablation (targeting benign thyroid remnant), adjuvant (targeting presumed microscopic DTC) and known disease (targeting macroscopic DTC) treatments. Some experts mostly rely on clinicopathologic assessment for recurrence risk to select patients for the <jats:sup>131<\/jats:sup>I treatment. Others, in addition, apply radioiodine imaging to guide their treatment planning, termed theranostics (aka theragnostics or radiotheragnostics). In patients with low\u2010risk DTC, remnant ablation rather than adjuvant treatment is generally recommended and, in this setting, the ATA recommends a low <jats:sup>131<\/jats:sup>I activity. <jats:sup>131<\/jats:sup>I adjuvant treatment is universally recommended in patients with high\u2010risk DTC (a primary tumor of any size with gross extrathyroidal extension) and is generally recommended in intermediate\u2010risk DTC (primary tumor &gt;4\u2009cm in diameter, locoregional metastases, microscopic extrathyroidal extension, aggressive histology or vascular invasion). The optimal amount of <jats:sup>131<\/jats:sup>I activity for adjuvant treatment is controversial, but experts reached a consensus that the <jats:sup>131<\/jats:sup>I activity should be greater than that for remnant ablation. The main obstacles to establishing timely evidence through randomized clinical trials for <jats:sup>131<\/jats:sup>I therapy include years\u2010to\u2010decades delay in recurrence and low disease\u2010specific mortality. This mini\u2010review is intended to update oncologists on the most recent clinical, pathologic, laboratory and imaging variables, as well as on the current <jats:sup>131<\/jats:sup>I therapy\u2010related definitions and management paradigms, which should optimally equip them for individualized patient guidance and treatment.<\/jats:p>","DOI":"10.1002\/ijc.33020","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T12:15:55Z","timestamp":1587557755000},"page":"2345-2354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Contemporary considerations in adjuvant radioiodine treatment of adults with differentiated thyroid cancer"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-8118","authenticated-orcid":false,"given":"Malik E.","family":"Juweid","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine\/Department of Radiology and Nuclear Medicine University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Tulchinsky","sequence":"additional","affiliation":[{"name":"Department of Radiology Penn State University Hershey Medical Center  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Mismar","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munther","family":"Momani","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman A.","family":"Zayed","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam","family":"Al Hawari","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader","family":"Albsoul","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix M.","family":"Mottaghy","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University of Aachen  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1501993"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3322-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19488"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21669"},{"key":"e_1_2_11_8_1","first-page":"298","article-title":"Thyroid cancers in nodular goiters in Kano, Nigeria","volume":"13","author":"Edino ST","year":"2010","journal-title":"Niger J Clin Pract"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0100"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0415"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-017-0182-7"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0253"},{"key":"e_1_2_11_13_1","unstructured":"LusterM AktolunC AmendoeiraI et al. 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