{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:34:15Z","timestamp":1787852055342,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003461","name":"Gunnar Nilssons Cancerstiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Women with lower levels of serum selenium (Se) may have a worse survival in breast cancer than women with higher levels, despite no difference in incidence of the disease. Our study was conducted to test whether Se is associated with the aggressiveness of breast tumors. Both the risk of having a tumor characteristic associated with worse prognosis, as well as the overall and breast cancer\u2010specific mortality, were studied. We identified breast cancer cases and controls within the Malm\u00f6 Diet and Cancer Study, a population\u2010based cohort with 17\u2009035 women recruited between 1991 and 1996. Inclusion criteria were incident breast cancer. Exclusion criteria were carcinoma in situ and bilateral breast cancer. Controls were selected among breast cancer\u2010free women both from matching (n = 694) as well as randomization (n = 492). After exclusion, 1066 cases remained and were compared to controls regarding their prediagnostic serum Se levels and subsequent risk of having a certain tumor characteristic or intrinsic subtype. We also followed breast cancer patients regarding overall and breast cancer\u2010specific mortality, comparing different Se quartiles. No association between serum Se quartile and any tumor characteristic or intrinsic subtype was found. Lower overall mortality was found among women in the highest Se quartile compared to the lowest using an adjusted Cox proportional hazards model, hazard ratio 0.63 (95% confidence interval: 0.44\u20100.89). Similar results were seen for breast cancer\u2010specific mortality, 0.60 (0.37\u20100.98). The results of our study support that Se is associated with a lower mortality in breast cancer, not related to established prognostic factors.<\/jats:p>","DOI":"10.1002\/ijc.33031","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T05:18:31Z","timestamp":1588828711000},"page":"2424-2436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Prediagnostic serum selenium levels in relation to breast cancer survival and tumor characteristics"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-5075","authenticated-orcid":false,"given":"Malte","family":"Sandsveden","sequence":"first","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital Malm\u00f6, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelie","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital Malm\u00f6, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Borgquist","sequence":"additional","affiliation":[{"name":"Department of Oncology Aarhus University Hospital, Aarhus University  Denmark"},{"name":"Department of Clinical Sciences Lund, Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann H.","family":"Rosendahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Division of Oncology and Pathology Lund University and Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-5289","authenticated-orcid":false,"given":"Jonas","family":"Manjer","sequence":"additional","affiliation":[{"name":"Department of Surgery Sk\u00e5ne University Hospital Malm\u00f6, Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0057-z"},{"key":"e_1_2_11_3_1","first-page":"CD005195","article-title":"Selenium for preventing cancer","volume":"1","author":"Vinceti M","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30875"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2139-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4525-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071811-150740"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2017.08.001"},{"issue":"12","key":"e_1_2_11_10_1","first-page":"3347","article-title":"Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium","volume":"63","author":"Hu YJ","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02685998"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf7444"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt303"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1702-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-6-606"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200112000-00003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1993.tb00647.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25215"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2000.00280.x"},{"key":"e_1_2_11_20_1","unstructured":"Malm\u00f6 Diet and Cancer Study and Malm\u00f6 Preventive Project [Webpage]. 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