{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:39:51Z","timestamp":1785458391854,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG049663"],"award-info":[{"award-number":["T32AG049663"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD is also a risk factor for prostate cancer (PC) require further investigation. We studied 218\u2009084 men in the population\u2010based UK Biobank cohort, aged 40 to 69 at study entry between 2006 and 2010, with follow\u2010up through mid\u20102015. We assessed the association between IBD and subsequent PC using multivariable Cox regression analyses, adjusting for age at assessment, ethnic group, UK region, smoking status, alcohol drinking frequency, body mass index, Townsend Deprivation Index, family history of PC and previous prostate\u2010specific antigen testing. Mean age at study entry was 56\u2009years, 94% of the men were white, and 1.1% (n = 2311) had a diagnosis of IBD. After a median follow\u2010up of 78\u2009months, men with IBD had an increased risk of PC (adjusted hazard ratio [aHR] = 1.31, 95% confidence interval [CI] = 1.03\u20101.67,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.029). The association with PC was only among men with the ulcerative colitis (UC; aHR = 1.47, 95% CI = 1.11\u20101.95,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.0070), and not Crohn's disease (aHR 1.06, 95% CI = 0.63\u20101.80,\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.82). Results are limited by lack of data on frequency of health care interactions. In a large\u2010scale, prospective cohort study, we detected an association between IBD, and UC specifically, with incident PC diagnosis.\n                  <\/jats:p>","DOI":"10.1002\/ijc.33048","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T04:26:19Z","timestamp":1589343979000},"page":"2735-2742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association between inflammatory bowel disease and prostate cancer: A large\u2010scale, prospective, population\u2010based study"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-9745","authenticated-orcid":false,"given":"Travis J.","family":"Meyers","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-8303","authenticated-orcid":false,"given":"Rebecca E.","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren Folgosa","family":"Cooley","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Catalona","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Hanauer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarki A.","family":"Abdulkadir","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilajit D.","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.12.062"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3710"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.04.033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000392"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-16-0124"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx046"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.03.034"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.11.039"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn595"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23666"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.249"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx040"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.760"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1199-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30183"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10163.x"},{"key":"e_1_2_10_24_1","unstructured":"The UK NSCrecommendation on Prostate cancer screening\/PSA testing in men over the age of 50. Available at:https:\/\/legacyscreening.phe.org.uk\/prostatecancer. ."},{"key":"e_1_2_10_25_1","unstructured":"UK Biobank: Protocol for a large\u2010scale prospective epidemiological resource. Amendment One Final March 21 2007. Available at:https:\/\/www.ukbiobank.ac.uk\/wp\u2010content\/uploads\/2011\/11\/UK\u2010Biobank\u2010Protocol.pdf?phpMyAdmin=trmKQlYdjjnQIgJ%2CfAzikMhEnx6. Accessed November 19 2019."},{"key":"e_1_2_10_26_1","unstructured":"MartinD.Townsend deprivation index. Geo\u2010Refer projects. Available at:http:\/\/www.restore.ac.uk\/geo-refer\/36229dtuks00y19810000.php. Published November 23 2007. Accessed February 26 2020."},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy073"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.167"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.186"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i36.13139"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170034"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000243"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0211"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a030361"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz104"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216526"},{"key":"e_1_2_10_37_1","unstructured":"Prostate cancer statistics. Cancer Research UK. Available at:https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/prostate-cancer. Published May 14 2015. Accessed February 26 2020."},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx246"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.33048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T11:23:21Z","timestamp":1693740201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,11,15]]}},"alternative-id":["10.1002\/ijc.33048"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33048","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.16.20017707","asserted-by":"object"}]},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,29]]},"assertion":[{"value":"2020-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}