{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:04:32Z","timestamp":1782698672717,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015\u201002332"],"award-info":[{"award-number":["2015\u201002332"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018\u201002825"],"award-info":[{"award-number":["2018\u201002825"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity is a risk factor for advanced, but not localised, prostate cancer (PCa), and for poor prognosis. However, the detection of localised PCa through asymptomatic screening might influence these associations. We investigated height and body mass index (BMI) among 431\u2009902 men in five Swedish cohorts in relation to PCa risk, according to cancer risk category and detection mode, and PCa\u2010specific mortality using Cox regression. Statistical tests were two\u2010sided. Height was positively associated with localised intermediate\u2010risk PCa (HR per 5\u2009cm, 1.03, 95% CI 1.01\u20101.05), while overweight and obesity were negatively associated with localised low\u2010 and intermediate\u2010risk PCa (HRs per 5 kg\/m<jats:sup>2<\/jats:sup>, 0.86, 95% CI 0.81\u20100.90, and 0.92, 95% CI 0.88\u20100.97). However, these associations were partially driven by PCa's detected by asymptomatic screening and, for height, also by symptoms unrelated to PCa. The HR of localised PCa's, per 5 kg\/m<jats:sup>2<\/jats:sup>, was 0.88, 95% CI 0.83 to 0.92 for screen\u2010detected PCa's and 0.96, 95% CI 0.90 to 1.01 for PCa's detected through lower urinary tract symptoms. BMI was positively associated with PCa\u2010specific mortality in the full population and in case\u2010only analysis of each PCa risk category (HRs per 5 kg\/m<jats:sup>2<\/jats:sup>, 1.11\u20101.22, <jats:italic>P<\/jats:italic> for heterogeneity = .14). More active health\u2010seeking behaviour among tall and normal\u2010weight men may partially explain their higher risk of localised PCa. The higher PCa\u2010specific mortality among obese men across all PCa risk categories in our study suggests obesity as a potential target to improve the prognosis of obese PCa patients.<\/jats:p>","DOI":"10.1002\/ijc.33150","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T16:09:44Z","timestamp":1591891784000},"page":"3328-3338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Height, body mass index and prostate cancer risk and mortality by way of detection and cancer risk category"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-1488","authenticated-orcid":false,"given":"Sylvia H. J.","family":"Jochems","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4r","family":"Stattin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6808-4405","authenticated-orcid":false,"given":"Christel","family":"H\u00e4ggstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Biobank Research Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Public Health and Clinical Medicine, Nutritional Research Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"J\u00e4rvholm","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marju","family":"Orho\u2010Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6 Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Stocks","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j477"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31553"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29842"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0876-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw225"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy219"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.09.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-0378-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.11.013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002118"},{"issue":"4","key":"e_1_2_10_13_1","first-page":"345","article-title":"Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States","volume":"10","author":"Rodriguez C","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0229"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.04.086"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0829-8"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2016.47"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0316-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys068"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.10.025"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3530"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532940"},{"key":"e_1_2_10_27_1","unstructured":"NORDCAN. 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