{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:22:17Z","timestamp":1790778137502,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"publisher","award":["703055"],"award-info":[{"award-number":["703055"]}],"id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insecticide use has been linked to increased risk of non\u2010Hodgkin lymphoma (NHL), however, findings of epidemiologic studies have been inconsistent, particularly for NHL subtypes. We analyzed 1690 NHL cases and 5131 controls in the North American Pooled Project (NAPP) to investigate self\u2010reported insecticide use and risk of NHL overall and by subtypes: follicular lymphoma (FL), diffuse large B\u2010cell lymphoma (DLBCL) and small lymphocytic lymphoma (SLL). Odds ratios (OR) and 95% confidence intervals for each insecticide were estimated using logistic regression. Subtype\u2010specific associations were evaluated using ASSET (Association analysis for SubSETs). Increased risks of multiple NHL subtypes were observed for lindane (OR = 1.60, 1.20\u20102.10: FL, DLCBL, SLL), chlordane (OR = 1.59, 1.17\u20102.16: FL, SLL) and DDT (OR = 1.36, 1.06\u20101.73: DLBCL, SLL). Positive trends were observed, within the subsets with identified associations, for increasing categories of exposure duration for lindane (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> =\u20091.7 \u00d7\u200910<jats:sup>\u22124<\/jats:sup>), chlordane (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> =\u20091.0 \u00d7\u200910<jats:sup>\u22123<\/jats:sup>) and DDT (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> =\u20094.2 \u00d7\u200910<jats:sup>\u22123<\/jats:sup>), however, the exposure\u2010response relationship was nonlinear. Ever use of pyrethrum was associated with an increased risk of FL (OR = 3.65, 1.45\u20109.15), and the relationship with duration of use appeared monotonic (OR for &gt;10\u2009years: OR = 5.38, 1.75\u201016.53; <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> =\u20093.6 \u00d7\u200910<jats:sup>\u22123<\/jats:sup>). Our analysis identified several novel associations between insecticide use and specific NHL subtypes, suggesting possible etiologic heterogeneity in the context of pesticide exposure.<\/jats:p>","DOI":"10.1002\/ijc.33164","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T20:31:59Z","timestamp":1592944319000},"page":"3370-3383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Insecticide use and risk of non\u2010Hodgkin lymphoma subtypes: A subset meta\u2010analysis of the North American Pooled Project"],"prefix":"10.1002","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3226-4727","authenticated-orcid":false,"given":"Linda","family":"Kachuri","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Beane Freeman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics U.S. National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Population Oncology BC Cancer  Vancouver British Columbia Canada"},{"name":"School of Population and Public Health University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Blair","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics U.S. National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Pahwa","sequence":"additional","affiliation":[{"name":"Occupational Cancer Research Centre Cancer Care Ontario  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-5485","authenticated-orcid":false,"given":"Stella","family":"Koutros","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics U.S. National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelia","family":"Hoar Zahm","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics U.S. National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth P.","family":"Cantor","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics U.S. National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis D.","family":"Weisenburger","sequence":"additional","affiliation":[{"name":"Department of Pathology City of Hope Medical Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punam","family":"Pahwa","sequence":"additional","affiliation":[{"name":"Canadian Centre for Health and Safety in Agriculture University of Saskatchewan  Saskatoon Saskatchewan Canada"},{"name":"Department of Community Health and Epidemiology, College of Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Dosman","sequence":"additional","affiliation":[{"name":"Department of Community Health and Epidemiology, College of Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Demers","sequence":"additional","affiliation":[{"name":"Occupational Cancer Research Centre Cancer Care Ontario  Toronto Ontario Canada"},{"name":"Division of Occupational &amp; Environmental Health, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Population Health and Prevention Cancer Care Ontario  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley A.","family":"Harris","sequence":"additional","affiliation":[{"name":"Occupational Cancer Research Centre Cancer Care Ontario  Toronto Ontario Canada"},{"name":"Division of Epidemiology, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Division of Occupational &amp; Environmental Health, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Population Health and Prevention Cancer Care Ontario  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60605-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_10_5_1","volume-title":"Cancer Epidemiology and Prevention","author":"Cerhan JR","year":"2017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0256438"},{"key":"e_1_2_10_7_1","volume-title":"Occupational Exposures in Insecticide Application, and some Pesticides","author":"International Agency for Research on Cancer","year":"1991"},{"key":"e_1_2_10_8_1","volume-title":"Some Organophosphate Insecticides and Herbicides: Diazinon, Glyphosate, Malathion, Parathion, and Tetrachlorvinphos","author":"International Agency for Research on Cancer","year":"2015"},{"key":"e_1_2_10_9_1","volume-title":"National Toxicology Program, Report on Carcinogens","author":"US Department of Health and Human Services","year":"2014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00081-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9061-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22719"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110404449"},{"key":"e_1_2_10_14_1","volume-title":"DDT, Lindane, and 2,4\u2010D","author":"International Agency for Research on Cancer","year":"2018"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30513-7"},{"key":"e_1_2_10_16_1","volume-title":"Some Thyrotropic Agents","author":"International Agency for Research on Cancer","year":"2001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.95103s7113"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/375581a0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.11.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx500323h"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11338"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901131"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109332"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2012-100845"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23589"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00053156"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199801)33:1<82::AID-AJIM9>3.0.CO;2-Y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199009000-00004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380090081023"},{"key":"e_1_2_10_30_1","first-page":"1155","article-title":"Non\u2010Hodgkin's lymphoma and specific pesticide exposures in men: cross\u2010Canada study of pesticides and health","volume":"10","author":"McDuffie HH","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/1059924X.2012.632339"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000183539.20100.06"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000083033.56116.c1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28191"},{"key":"e_1_2_10_35_1","first-page":"675","article-title":"Nonconcurrence in abstracted diagnoses of non\u2010Hodgkin's lymphoma","volume":"78","author":"Dick FR","year":"1987","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_10_36_1","first-page":"2447","article-title":"Pesticides and other agricultural risk factors for non\u2010Hodgkin's lymphoma among men in Iowa and Minnesota","volume":"52","author":"Cantor KP","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.03.015"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9469.2011.00760.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287390903091780"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(93)90077-C"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22258"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.8.522"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.60.9.e11"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23005"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3906"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1103573"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2007.033548"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.4347"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32350"},{"key":"e_1_2_10_51_1","unstructured":"UEP Agency Chemicals Evaluated for Carcinogenic Potential: CAS no. 52645\u201353\u20101 2007."},{"key":"e_1_2_10_52_1","first-page":"6585","article-title":"Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota","volume":"50","author":"Brown LM","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11318"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199301000-00011"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.13031\/2013.17760"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200201000-00015"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116096"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.03.018"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.626"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.419"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3105"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14175"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-153858"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9429-5"},{"key":"e_1_2_10_65_1","unstructured":"Stockholm Convention on Persistent Organic Pollutants Report of the Third Meeting of the Expert Group on the assessment of the production and use of DDT and its alternatives for disease vector control 2010."},{"key":"e_1_2_10_66_1","volume-title":"Global status of DDT and its alternatives for use in vector control to prevent disease","author":"Berg H","year":"2008"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.33164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.33164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.33164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:49:43Z","timestamp":1693417783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.33164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":65,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,15]]}},"alternative-id":["10.1002\/ijc.33164"],"URL":"https:\/\/doi.org\/10.1002\/ijc.33164","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"assertion":[{"value":"2019-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}