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The utility of these variants in assessing risk of esophageal, gastric and endometrial cancers, as well as melanoma, glioma, diffuse large B\u2010cell lymphoma, follicular lymphoma, chronic lymphoid leukemia and multiple myeloma, has not been adequately investigated. We constructed a site\u2010specific polygenic risk score (PRS) for each of these nine cancers using their GWAS\u2010identified risk variants. Using data from 400\u2009807 participants of European descent in the UK Biobank, a population\u2010based cohort study, we estimated the hazard ratios of each cancer associated with its PRS using Cox proportional hazard models. During a median follow\u2010up of 5.8\u2009years, 3905 incident cases of these nine cancers were identified in the cohort. The area under the receiver operating characteristic curve ranged from 0.53 to 0.69 for these cancers. Except for esophageal cancer, significant dose\u2010response associations were observed between PRS and cancer risk. Compared to individuals in the middle quintile (40%\u201060%) at an average risk, those among the highest 5% of the PRS had a twofold elevated risk of melanoma, glioma, follicular lymphoma or multiple myeloma, and a fourfold elevated risk of chronic lymphoid leukemia. Using PRS, 63.0% of the participants could be classified as having an over twofold elevated risk for at least one cancer. The PRS derived using risk variants identified to date by GWAS showed the potential in identifying individuals at a significantly elevated risk of cancer for prevention.<\/jats:p>","DOI":"10.1002\/ijc.33176","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T05:56:30Z","timestamp":1593150990000},"page":"3416-3423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evaluating polygenic risk scores in assessing risk of nine solid and hematologic cancers in European descendants"],"prefix":"10.1002","volume":"147","author":[{"given":"Jungyoon","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt\u2010Ingram Cancer Center Vanderbilt University Medical Center  Nashville Tennessee 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