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Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al reported that L1CAM identifies metastasis\u2010initiating cells in colorectal carcinoma exhibiting stem\u2010like cell features, increased tumorigenic potential and enhanced chemoresistance. In this review, we highlight recent advances in L1CAM research with particular emphasis on its role in de\u2010differentiation processes and cancer cell stemness supporting the view that L1CAM is a powerful prognostic factor and a suitable target for improved therapy of metastatic and drug\u2010resistant tumors.<\/jats:p>","DOI":"10.1002\/ijc.33177","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T05:56:38Z","timestamp":1593150998000},"page":"3292-3296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Recent insights into the role of <scp>L1CAM<\/scp> in cancer initiation and progression"],"prefix":"10.1002","volume":"147","author":[{"given":"Peter","family":"Altevogt","sequence":"first","affiliation":[{"name":"Skin Cancer Unit, German Cancer Research Center (DKFZ) and Department of Dermatology, Venereology and Allergology University Medical Center Mannheim  Heidelberg 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