{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:12:01Z","timestamp":1792087921135,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"The National Cancer Institute","doi-asserted-by":"publisher","award":["Intramural Research Program"],"award-info":[{"award-number":["Intramural Research Program"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Certain population groups are known to have higher than average anal cancer risk, namely persons living with HIV (PLHIV), men who have sex with men (MSM), women diagnosed with human papillomavirus (HPV)\u2010related gynecological precancerous lesions or cancer, solid organ transplant recipients (SOTRs) and patients with autoimmune diseases. Our aim was to provide robust and comparable estimates of anal cancer burden across these groups. Summary incidence rates (IRs), as cases per 100\u2009000 person\u2010years (py), were calculated by fixed\u2010effects meta\u2010analysis. IRs were 85 (95% confidence interval [CI] = 82\u201089) for HIV\u2010positive MSM (n = 7 studies; 2 229\u2009234\u2009py), 32 (95% CI = 30\u201035) for non\u2010MSM male PLHIV (n = 5; 1626\u2009448\u2009py) and 22 (95% CI = 19\u201024) for female PLHIV (n = 6; 1 472\u2009123\u2009py), with strong variation by age (eg, from 16.8\u2009&lt;\u200930\u2009years to 107.5\u2009\u2265\u200960\u2009years for HIV\u2010positive MSM). IR was 19 (95% CI = 10\u201036) in HIV\u2010negative MSM (n = 2; 48\u2009135\u2009py). Anal cancer IRs were much higher after diagnosis of vulvar (IR = 48 [95% CI = 38\u201061]; n = 4; 145\u2009147\u2009py) than cervical (9 [95% CI = 8\u201012]; n = 4; 779\u2009098\u2009py) or vaginal (IR = 10 [95% CI = 3\u201030]; n = 4; 32\u2009671) cancer, with equivalent disparity after respective precancerous lesions. IR was 13 (95% CI = 12\u201015) in SOTRs (n = 5; 1 946\u2009206\u2009py), reaching 24.5 and 49.6 for males and females &gt;10\u2009years after transplant. Anal cancer IRs were 10 (95% CI = 5\u201019), 6 (95% CI = 3\u201011) and 3 (95% CI = 2\u20104) for systemic lupus erythematosus, ulcerative colitis and Crohn's disease, respectively. In conclusion, a unifying anal cancer risk scale, based upon comprehensive meta\u2010analysis, can improve prioritization and standardization in anal cancer prevention\/research initiatives, which are in their public health infancy.<\/jats:p>","DOI":"10.1002\/ijc.33185","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T18:50:35Z","timestamp":1593888635000},"page":"38-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":497,"title":["A meta\u2010analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-333X","authenticated-orcid":false,"given":"Gary M.","family":"Clifford","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Georges","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith S.","family":"Shiels","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Engels","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-2987","authenticated-orcid":false,"given":"Andreia","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"St James University Hospital  Leeds UK"},{"name":"CINTESIS \u2010 Center for Health Technology and Services Research, Faculty of Medicine, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-3769","authenticated-orcid":false,"given":"Isobel Mary","family":"Poynten","sequence":"additional","affiliation":[{"name":"Kirby Institute, University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"de Pokomandy","sequence":"additional","affiliation":[{"name":"Chronic Viral Illness Service, McGill University Health Centre and Department of Family Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Easson","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Stier","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30488-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix582"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000508"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000256"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30164-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20365"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30434-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70080-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61050-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0273-9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15942"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs371"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.11.004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.9291"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12472"},{"key":"e_1_2_10_17_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program (www.seer.cancer.gov) Research Data 1973\u20132016. 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