{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:08:48Z","timestamp":1790968128561,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["KWF 2016\u201010382"],"award-info":[{"award-number":["KWF 2016\u201010382"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The risk of vulvar squamous cell carcinoma (VSCC) in patients with high\u2010grade vulvar intraepithelial neoplasia (VIN) is considered lower in high\u2010grade squamous intraepithelial lesion (HSIL) compared to differentiated VIN (dVIN), but studies are limited. Our study investigated both the incidence of high\u2010grade VIN and the cumulative incidence of VSCC in patients with HSIL and dVIN separately. A database of women diagnosed with high\u2010grade VIN between 1991 and 2011 was constructed with data from the Dutch Pathology Registry (PALGA). The European standardized incidence rate (ESR) and VSCC risk were calculated, stratified for HSIL and dVIN. The effects of type of VIN (HSIL vs dVIN), age and lichen sclerosis (LS) were estimated by Cox regression. In total, 1148 patients were diagnosed with high\u2010grade VIN between 1991 and 2011. Between 1991\u20101995 and 2006\u20102011, the ESR of HSIL increased from 2.39 (per 100\u2009000 woman\u2010years) to 3.26 and the ESR of dVIN increased from 0.02 to 0.08. The 10\u2010year cumulative VSCC risk was 10.3%; 9.7% for HSIL and 50.0% for dVIN (log rank\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Type of VIN, age and presence of LS were independent risk factors for progression to VSCC, with hazard ratios of 3.0 (95% confidence interval [CI] 1.3\u20107.1), 2.3 (95% CI 1.5\u20103.4) and 3.1 (95% CI 1.8\u20105.3), respectively. The incidence of high\u2010grade VIN is rising. Because of the high cancer risk in patients with dVIN, better identification and timely recognition are urgently needed.\n                  <\/jats:p>","DOI":"10.1002\/ijc.33198","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T01:55:54Z","timestamp":1594173354000},"page":"90-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Vulvar intraepithelial neoplasia: Incidence and long\u2010term risk of vulvar squamous cell carcinoma"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-5609","authenticated-orcid":false,"given":"Nikki B.","family":"Thuijs","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"van Beurden","sequence":"additional","affiliation":[{"name":"Antoni van Leeuwenhoek hospital Department of Gynaecology  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette H.","family":"Bruggink","sequence":"additional","affiliation":[{"name":"PALGA Foundation  Houten The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renske D. M.","family":"Steenbergen","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Berkhof","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics Amsterdam Public Health  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike C. G.","family":"Bleeker","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.04.021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2018-000135"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.02.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.03.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.197"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1302"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30821"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001285"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24116"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0019"},{"key":"e_1_2_10_13_1","unstructured":"Central office for statistics (CBS). 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