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The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy\u2010corrected mortality rates of corpus uteri cancer, overall and stratified by age, stage and histologic subtype. Using data from nationwide Danish registries, we calculated uncorrected and hysterectomy\u2010corrected age\u2010standardized mortality rates of corpus uteri cancer among women \u226535\u2009years during 2002 to 2015. Individual\u2010level hysterectomy status was obtained from national registries; hysterectomy\u2010corrected mortality rates were calculated by subtracting posthysterectomy person\u2010years from the denominator, unless hysterectomy was performed due to corpus uteri cancer. Correction for hysterectomy resulted in a 25.5% higher mortality rate (12.3\/100000 person\u2010years vs 9.8\/100000 person\u2010years). Mortality rates were highest in women aged 70+, irrespective of year of death, histologic subtype and stage. A significant decline was observed in overall hysterectomy\u2010corrected mortality rates from 2002 to 2015, particularly among women aged 70+. Mortality rates of endometrioid cancer declined significantly over time (annual percent change [APC]: \u22122.32, 95% CI \u22123.9, \u22120.7, <jats:italic>P<\/jats:italic> = .01), whereas rates of nonendometrioid cancer increased (APC: 5.90, 95% CI: 3.0, 8.9, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). With respect to stage, mortality rates increased significantly over time for FIGOI\u2010IIa (APC: 6.18 [95% CI: 1.9, 10.7] <jats:italic>P<\/jats:italic> = .01) but remained unchanged for FIGO IIb\u2010IV. In conclusion, increasing mortality rates of nonendometrioid cancer paralleled the previously observed rise in incidence rates of this histologic subtype. Given the poor prognosis of nonendometrioid cancer, more studies are needed to clarify the underlying reason for these findings.<\/jats:p>","DOI":"10.1002\/ijc.33219","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T15:30:30Z","timestamp":1595172630000},"page":"584-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trends in hysterectomy\u2010corrected uterine cancer mortality rates during 2002 to 2015: mortality of nonendometrioid cancer on the rise?"],"prefix":"10.1002","volume":"148","author":[{"given":"Line W.","family":"Gustafson","sequence":"first","affiliation":[{"name":"Department of Public Health Programmes Randers Regional Hospital  Randers Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit B.","family":"Booth","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Gynecology and Obstetrics Randers Regional Hospital  Randers Denmark"},{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Kahlert","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"\u00d8rtoft","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else","family":"Mejlgaard","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-7376","authenticated-orcid":false,"given":"Megan A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-0836","authenticated-orcid":false,"given":"Nicolas","family":"Wentzensen","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne F.","family":"Rositch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4616-9827","authenticated-orcid":false,"given":"Anne","family":"Hammer","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Gynecology and Obstetrics Regional Hospital West Jutland  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_3_1","unstructured":"EngholmG FerlayJ ChristensenN et al. 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