{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:40:40Z","timestamp":1787060440802,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2021,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In Oceania, North America and north\u2010western Europe, after decades of increase, cutaneous malignant melanoma (CMM) rates began to stabilise or decline before 2000. Anecdotal evidence suggests that the reversal of the incidence trend is extending to southern Europe. To obtain a formal confirmation, this nationwide study from Italy investigated the incidence trends by birth cohort. Twenty\u2010one local cancer registries covering a population of 15\u2009814\u2009455 provided incidence data for primary CMM registered between 1994 and 2013. Trends in age\u2010standardised rates were analysed using joinpoint regression models and age\u2010period\u2010cohort models. Age\u2010standardised incidence showed a consistent increase throughout the period (estimated annual percent change, 3.6 [95% confidence interval, 3.2\u20104.0] among men and 2.5 [2.0\u20103.1] among women). This pattern was confirmed by a sensitivity analysis with removal of low\u2010risk populations of southern Italy. The rates, however, showed a stabilisation or a decrease in men and women aged below 35. Using the cohort of 1949\u2014the median cohort with respect to the number of cases for both genders\u2014as a reference, the incidence rate ratio increased for successive cohorts born until 1973 (women) and 1975 (men), and subsequently tended to decline. For the most recent cohorts in both genders, the risk of disease returned to the level of the cohort of 1949. The changes observed in the latest generations can be interpreted as the earliest manifestations of a birth\u2010cohort\u2010dependent incidence decrease. Our study adds to previous data indicating that the reversal of the long\u2010term upward incidence trend of CMM is extending to southern Europe.<\/jats:p>","DOI":"10.1002\/ijc.33259","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:22:51Z","timestamp":1598606571000},"page":"835-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Mid\u2010term trends and recent birth\u2010cohort\u2010dependent changes in incidence rates of cutaneous malignant melanoma in Italy"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6771-8119","authenticated-orcid":false,"given":"Lauro","family":"Bucchi","sequence":"first","affiliation":[{"name":"Romagna Cancer Registry Romagna Cancer Institute, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS  Meldola, Forl\u00ec 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