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In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3\u2009years. Forty\u2010nine GC events were observed in 47 patients. <jats:italic>MLH1<\/jats:italic> (n = 21) and <jats:italic>MSH2<\/jats:italic> (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early\u2010stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; <jats:italic>P<\/jats:italic> = .0231). Thirty\u2010two (68%) patients had a negative family history of GC. The median age at diagnosis was 51\u2009years (range 28\u201066). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30.<\/jats:p>","DOI":"10.1002\/ijc.33294","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T19:25:52Z","timestamp":1600716352000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Value of upper <scp>gastrointestinal<\/scp> endoscopy for gastric cancer surveillance in patients with Lynch syndrome"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1923-4096","authenticated-orcid":false,"given":"Swetlana","family":"Ladigan\u2010Badura","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Knappschaftskrankenhaus Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak B.","family":"Vangala","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Knappschaftskrankenhaus Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-282X","authenticated-orcid":false,"given":"Christoph","family":"Engel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolin","family":"Bucksch","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hueneburg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital of Bonn  Bonn Germany"},{"name":"Center for Hereditary Tumor Syndromes University Hospital of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Perne","sequence":"additional","affiliation":[{"name":"Center for Hereditary Tumor Syndromes University Hospital of Bonn  Bonn Germany"},{"name":"Institute of Human Genetics University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Nattermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-3234","authenticated-orcid":false,"given":"Verena","family":"Steinke\u2010Lange","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Campus Innenstadt Klinikum der Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"MGZ \u2013 Medizinisch Genetisches Zentrum  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Rahner","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Medical School Heinrich Heine University  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans K.","family":"Schackert","sequence":"additional","affiliation":[{"name":"Department of Surgery Technische Universit\u00e4t  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Weitz","sequence":"additional","affiliation":[{"name":"Department of Surgery Technische Universit\u00e4t  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kloor","sequence":"additional","affiliation":[{"name":"Department of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg, Germany; and Cooperation Unit Applied Tumor Biology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Kuhlkamp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Knappschaftskrankenhaus Ruhr University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huu Phuc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute for Human Genetics Ruhr\u2010University  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Moeslein","sequence":"additional","affiliation":[{"name":"Ev. 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