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Therefore, we investigated the association between WC representing central obesity and the risk of HCC in addition to BMI representing general obesity and the risk of HCC in Korea. A total of 10\u2009505\u2009818 participants who received the National Health Insurance Service (NHIS) health checkups in 2009 were screened for study eligibility, and 26\u2009979 cases of HCC occurred during the 7.3\u2009years of mean follow\u2010up. General obesity increased the risk of HCC with hazard ratios (HRs) of 1.14 (95% CI, 1.11\u20101.18) for BMI 25.0\u2010&lt;30.0 kg\/m<jats:sup>2<\/jats:sup> and 1.52 (95% CI, 1.43\u20101.61) for BMI \u226530\u2009kg\/m<jats:sup>2<\/jats:sup> compared to those whose BMI is within the normal range. Central obesity was also associated with a higher risk of HCC. For the participants with a WC \u2265105\u2009cm in men and WC \u2265100\u2009cm in women, the risk of HCC was higher than that of the reference group (HR = 1.69, 95% CI, 1.54\u20101.85). The HRs were 1.13 (95% CI, 1.07\u20101.19) for nonobese participants with central obesity, and 1.34 (95% CI, 1.30\u20101.38) for obese participants with central obesity compared to those without both conditions. Our findings suggest that the risk of HCC increases even more when general obesity is combined with central obesity. Moreover, central obesity is associated with the risk of HCC, regardless of general obesity.<\/jats:p>","DOI":"10.1002\/ijc.33305","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T19:25:05Z","timestamp":1600716305000},"page":"1144-1154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Associations of general obesity and central obesity with the risk of hepatocellular carcinoma in a Korean population: A national <scp>population\u2010based<\/scp> cohort study"],"prefix":"10.1002","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-1117","authenticated-orcid":false,"given":"Seawon","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of internal medicine, Graduate school of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-6879","authenticated-orcid":false,"given":"Yong\u2010Moon","family":"Park","sequence":"additional","affiliation":[{"name":"Epidemiology Branch, National Institute of Environmental Health Sciences National Institutes of Health  Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science Soongsil University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Seung","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine St. Vincent's Hospital, College of Medicine, The Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Hyun","family":"Ko","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine St. Vincent's Hospital, College of Medicine, The Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Bae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine St. Vincent's Hospital, College of Medicine, The Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-1168","authenticated-orcid":false,"given":"Jae Hyun","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary\u2010Pancreas Surgery and Liver Transplantation, Department of Surgery St. Vincent's Hospital, College of Medicine, The Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_11_3_1","unstructured":"National Cancer Information Center.National Cancer Registration and Statistics 2017; 2019.https:\/\/www.cancer.go.kr\/lay1\/S1T639C641\/contents.do. 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